ReviewReviews in endocrine & metabolic disorders2007
The hypothalamic-pituitary-adrenal axis in critical illness.
Review in Reviews in endocrine & metabolic disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Does elite European match-play affect salivary immunoglobulin-A and cortisol in soccer players? The influence of playing status and match outcome.Frontiers in physiology · 2024Article
- The Immunological and Hormonal Responses to Competitive Match-Play in Elite Soccer Players.International journal of environmental research and public health · 2022Article
- Article
- Comparison of total, salivary and calculated free cortisol levels in patients with severe sepsis.Journal of intensive care · 2016Article
- 'Chronomics' in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill.Intensive care medicine experimental · 2014Article
- Adrenal insufficiency presenting as bilateral rigid auricles: a case report.Journal of medical case reports · 2014Article
- Irregularities in glucose metabolism induced by stress and high-calorie diet can be attenuated by glycyrrhizic acid.International journal of physiology, pathophysiology and pharmacology · 2014Article
- How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration.The Journal of clinical endocrinology and metabolism · 2013Article
- Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in Rats Fed on a Combination of High-Fat and High-Sucrose Diet with Glycyrrhizic Acid.Journal of diabetes research · 2013Article
- Dynamic regulation of glucocorticoid signalling in health and disease.Rheumatology (Oxford, England) · 2012Review
- Serum free cortisol index, free cortisol, and total cortisol in critically ill children.Intensive care medicine · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Hypothalamic-pituitary-adrenal (HPA) axis function is crucial to maintain and restore homeostasis. The HPA axis does not function in isolation. Rather, the HPA axis modulates and reacts to signals from endocrine, neural, and immune systems. Cortisol is the major glucocorticoid secreted by the human adrenal cortex. Its actions are largely mediated by the glucocorticoid receptor. The potent anti-inflammatory actions of glucocorticoids led to their use in critically ill patients. Metaanalyses of these early studies (before 1985) concluded that large glucocorticoid doses had no effect and were potentially detrimental. More recently, the pendulum has swung in the opposite direction based on the concept that critically ill patients may have relative adrenal insufficiency and/or acquired glucocorticoid resistance. However, inconsistent diagnostic criteria, heterogeneity of subjects, variable nutritional status, and pre-existing conditions preclude formulating definitive conclusions regarding glucocorticoid use among critically patients. Diagnosing adrenal insufficiency in the critically ill patient remains challenging. To resolve the issue, our challenge is to develop physiologically relevant tools to assess glucocorticoid action and GR function at the cellular level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.