ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2008
Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: results of a study assessing a panel of angiogenic markers.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Prognostic value of vascular endothelial growth factor A expression in gastric cancer: a meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Cyclooxygenase-2 expression is associated with poor overall survival of patients with gastric cancer: a meta-analysis.Digestive diseases and sciences · 2014Pooled it
- Prognostic significance of vascular endothelial growth factor immunohistochemical expression in gastric cancer: a meta-analysis.Molecular biology reports · 2012Pooled it
- Global trends in oncology research: A mixed-methods study of publications and clinical trials from 2010 to 2019.Cancer reports (Hoboken, N.J.) · 2023Article
- The Mechanism of Osthole in the Treatment of Gastric Cancer Based on Network Pharmacology and Molecular Docking Technology.Applied bionics and biomechanics · 2022Article
- Correlations between VEGF-A expression and prognosis in patients with gastric adenocarcinoma.International journal of clinical and experimental pathology · 2017Article
- Radiologic Features and Expression of Vascular Endothelial Growth Factor Stratify Survival Outcomes in Patients with Glioblastoma.AJNR. American journal of neuroradiology · 2016Article
- Article
- The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis.PloS one · 2015Article
- Role of cyclooxygenase-2 in gastric cancer development and progression.World journal of gastroenterology · 2013Review
- Hypoxia-inducible factor-1α overexpression indicates poor clinical outcomes in tongue squamous cell carcinoma.Experimental and therapeutic medicine · 2013Article
- β -Elemene-Attenuated Tumor Angiogenesis by Targeting Notch-1 in Gastric Cancer Stem-Like Cells.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Correlation of vascular endothelial growth factor expression with tumor recurrence and poor prognosis in patients with pN0 gastric cancer.World journal of surgery · 2012Article
- Pulmonary tumor thrombotic microangiopathy induced by gastric carcinoma: morphometric and immunohistochemical analysis of six autopsy cases.Diagnostic pathology · 2011Article
- STAT-3 correlates with lymph node metastasis and cell survival in gastric cancer.World journal of gastroenterology · 2010Article
- Use of positron emission tomography in surgery follow-up of esophageal cancer.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients.Digestive diseases and sciences · 2009Article
- Current status and future of chemotherapy and biochemotherapy in gastroesophageal cancers.Gastrointestinal cancer research : GCR · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) contribute to gastric cancer aggressiveness by up-regulating the expression of proteases. We evaluated the expression and the prognostic significance of angiogenic factors and proteases in 148 patients with R0-resected gastric cancer. Expression of VEGF, Ang-2, cyclooxygenase-2 (COX-2), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1, matrix metalloproteinases (MMP)-1 and -9 were assayed by immunohistochemistry. After a mean of 63 +/- 4 months, 81 out of 148 patients had died due to disease. The probability of being free of recurrence was 62, 48, and 42% at 2, 5, and 10 years, respectively. Single bivariate analysis identified VEGF, Ang-2, COX-2, PAI-1, and MMP-9 expression, along with several clinicopathological parameters (grade of curability, lymph node ratio, pTNM, pT, pN), as variables associated with both decreased disease-specific survival and recurrence. On multivariate analysis, after adjusting for significant clinical covariables, positive VEGF immunostaining was the primary prognostic factor, and no other tumor marker variable could add any significant improvement for the prediction, for both disease-specific survival (p = 0.001; HR, 3.27; 95% CI, 1.76 to 6.10) and tumor recurrence (p = 0.002; HR, 2.81; 95% CI, 1.48 to 5.35). Our study suggests that VEGF alone may be clinically useful for establishing therapeutic decisions in gastric cancer patients.
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