ArticleVirchows Archiv : an international journal of pathology2007
Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis.
Article in Virchows Archiv : an international journal of pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Inhibition of cIAP1/2 reduces RIPK1 phosphorylation in pulmonary endothelial cells and alleviate sepsis-induced lung injury and inflammatory response.Immunologic research · 2024Article
- IAPs and RIPK1 mediate LPS-induced cytokine production in healthy subjects and Crohn's disease.Clinical and experimental immunology · 2024Article
- The Role of E3 Ubiquitin Ligases and Deubiquitinases in Inflammatory Bowel Disease: Friend or Foe?Frontiers in immunology · 2021Review
- Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Altered expression of Tumor Necrosis Factor Alpha -Induced Protein 3 correlates with disease severity in Ulcerative Colitis.Scientific reports · 2017Article
- Exome Analysis of Rare and Common Variants within the NOD Signaling Pathway.Scientific reports · 2017Article
- Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.Inflammatory bowel diseases · 2016Review
- A critical role for cellular inhibitor of protein 2 (cIAP2) in colitis-associated colorectal cancer and intestinal homeostasis mediated by the inflammasome and survival pathways.Mucosal immunology · 2016Article
- ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis.Journal of molecular medicine (Berlin, Germany) · 2013Article
- Gene signature distinguishes patients with chronic ulcerative colitis harboring remote neoplastic lesions.Inflammatory bowel diseases · 2013Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has been reported that colonocytes in ulcerative colitis (UC) upregulate anti-apoptotic cytoprotective pathways. An expression-profiling study of apoptosis-related genes suggested that the cellular inhibitor of apoptosis protein-2 (cIAP2) could be upregulated in epithelial cells in UC. The role of cIAP2 in active UC was therefore investigated. Fourteen patients with active UC and 12 control subjects who underwent routine colonoscopy for control of their disease or as part of their examination program for irritable bowel syndrome were included. cIAP1 and cIAP2 expression was investigated by polymerase chain reaction, Western blotting, and immunohistochemistry. The regulation and role of cIAP2 for apoptosis was further investigated in cell cultures. cIAP2, but not cIAP1, was upregulated during active UC in regenerative epithelial cells. A similar upregulation was found in cell lines stimulated with proinflammatory cytokines and was dependent on nuclear factor kappaB activation. Inhibition of cIAP2 increases the susceptibility of epithelial cells to Fas ligation. Inflammation during active UC thus causes an upregulation of cIAP2 in regenerating epithelium, which renders the cells less susceptible to Fas ligation. This might play a role in regeneration of the epithelium but might additionally be implicated in carcinogenesis of UC.
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