Trial reportEuropean journal of clinical nutrition2009
Efficacy and safety of twice-weekly administration of three RDAs of iron and folic acid with and without complement of 14 essential micronutrients at one or two RDAs: a placebo-controlled intervention trial in anemic Cambodian infants 6 to 24 months of age.
Trial report in European journal of clinical nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Food fortification with multiple micronutrients: impact on health outcomes in general population.The Cochrane database of systematic reviews · 2019Pooled it
- Vitamin D supplementation for preventing infections in children under five years of age.The Cochrane database of systematic reviews · 2016Pooled it
- Oral iron supplements for children in malaria-endemic areas.The Cochrane database of systematic reviews · 2016Pooled it
- Intermittent iron supplementation for improving nutrition and development in children under 12 years of age.The Cochrane database of systematic reviews · 2011Pooled it
- Consumption of Sinlek Rice Drink Improved Red Cell Indices in Anemic Elderly Subjects.Molecules (Basel, Switzerland) · 2021Trial
- Trial
- Prevention and Treatment of Anemia in Infants through Supplementation, Assessing the Effectiveness of Using Iron Once or Twice Weekly.Journal of tropical pediatrics · 2016Trial
- Efficacy of different strategies to treat anemia in children: a randomized clinical trial.Nutrition journal · 2010Trial
- Review of dietary assessment studies conducted among Khmer populations living in Cambodia.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022Review
- Iron Fortification and Supplementation: Fighting Anemia of Chronic Diseases or Fueling Obesity?Current developments in nutrition · 2021Article
- Perspective: What Makes It So Difficult to Mitigate Worldwide Anemia Prevalence?Advances in nutrition (Bethesda, Md.) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the differential efficacy and safety of twice-weekly administration of 3 RDAs of iron and folic acid, with and without a complement of 2 RDAs of 11, and 1 RDA of 3 additional essential micronutrients as compared to a placebo control (PlbCON) given as foodLETs. SUBJECTS/
methodsA total of 250 children aged 6-24 months were enrolled after recruitment by village health workers; 19 of them dropped out during the trial. Children were assigned to one of three treatment arms and followed for 20.5 weeks; 41 supervised twice-weekly dosings of 30 mg of iron plus folic acid, either with or without accompanying micronutrients or placebo were given as foodLETs, a tool for ready-to-eat fortification in infant food. Initial and final measurements of anthropometry and blood biomarkers for hematological, iron stores and inflammatory status, as well as for abnormal hemoglobin (Hb), were obtained. Symptoms of listlessness, vomiting, watery stools and acute respiratory infections were monitored weekly.
resultsIron-containing supplements increased Hb concentrations significantly (P<0.0001) and virtually eradicated any IDA, as compared to no change in hematological status in the PlbCON group (P=0.011). Iron stores, as reflected by ferritin, increased significantly with iron-containing treatments (P<0.0001). Responses were as effective in individuals with HbE as in those with exclusively HbA phenotypes. Watery stools (P=0.002) and listlessness (P=0.001) were significantly more frequent in those receiving iron and folic acid alone than in the PlbCON group. In contrast, acute respiratory infections (P=0.014) and listlessness (P=0.001) were significantly less frequent in those receiving the multiple micronutrient formulation than in the PlbCON group.
conclusionsSupplementation of micronutrients along with iron and folic acid mitigates the excess morbidity of iron-folate alone, without reducing its efficacy in correcting anemia and building iron stores. FoodLETs are a suitable vehicle to provide micronutrient supplementation to infants.
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