ArticleAnnals of general psychiatry2007
Depression and anxiety in epilepsy: the association with demographic and seizure-related variables.
Article in Annals of general psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 129 citations in OpenAlex.
- Modelling risk factors for depressive symptoms in seizure disorders.Therapeutic advances in neurological disorders · 2026Article
- Co-morbid seizures in frontotemporal dementia: What do they tell us?Epilepsy research · 2025Article
- Real world testing and cost-effectiveness analysis of subcutaneous EEG (REAL-ASE): Protocol for a prospective multicentre interventional trial.Epilepsia open · 2025Article
- Perioperative Management of Patients With Seizure Disorders: Part I.Anesthesia progress · 2025Review
- Cerebral blood flow increases in idiopathic generalized epilepsy and its relationship with mood dysfunction.Epilepsia open · 2025Article
- Depression and Anxiety Among Patients with Epilepsy: A Cross-Sectional Study in Saudi Arabia.Brain sciences · 2025Article
- Influence of comorbid anxiety and depression disorder on cognition in older adults with epilepsy.Frontiers in psychiatry · 2025Article
- Influence of Epilepsy Characteristics on the Anxiety Occurrence.Brain sciences · 2024Article
- Prevalence and associated factors of psychiatric comorbidities in epilepsy in the Casablanca-Settat region of Morocco: A cross-sectional study.Epilepsia open · 2024Article
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- Screening of Major Depression Disorder in Patients With Epilepsy in Indonesian National Referral Hospital.Neurology. Clinical practice · 2023Article
- Afraid to go out: Poor quality of life with phobic anxiety in a large cross-sectional adult epilepsy center sample.Epilepsy research · 2023Article
- Effects of the hospital-community-family ternary linkage continuous nursing model on compliance, cognitive function, resilience, and quality of life for children with epilepsy: a retrospective study.Translational pediatrics · 2022Article
- Positive anxiety or depression screen despite ongoing antidepressant prescription in people with epilepsy: A large cross-sectional analysis.Epilepsy & behavior reports · 2022Article
- Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention.Frontiers in integrative neuroscience · 2022Review
- Anxiety and depression among epilepsy patients in low-risk areas for COVID-19 in the northern part of Guizhou Province, China, during the COVID-19 pandemic.Acta epileptologica · 2022Article
- Remote and Long-Term Self-Monitoring of Electroencephalographic and Noninvasive Measurable Variables at Home in Patients With Epilepsy (EEG@HOME): Protocol for an Observational Study.JMIR research protocols · 2021Article
- Quality of life in paediatrics with intractable epilepsy in a large paediatric university hospital in Riyadh, Saudi Arabia.Journal of family medicine and primary care · 2020Article
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Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression and anxiety are common psychiatric symptoms in patients with epilepsy, exerting a profound negative effect on health-related quality of life. Several issues, however, pertaining to their association with psychosocial, seizure-related and medication factors, remain controversial. Accordingly, the present study was designed to investigate the association of interictal mood disorders with various demographic and seizure-related variables in patients with newly-diagnosed and chronic epilepsy.
methodsWe investigated 201 patients with epilepsy (51.2% males, mean age 33.2 +/- 10.0 years, range 16-60) with a mean disease duration of 13.9 +/- 9.5 years. Depression and anxiety were assessed in the interictal state with the Beck Depression Inventory, 21-item version (BDI-21) and the state and trait subscales of the State-Trait Anxiety Inventory (STAI-S and STAI-T), respectively. The association of mood disorders with various variables was investigated with simple and multiple linear regression analyses.
resultsHigh seizure frequency and symptomatic focal epilepsy (SFE) were independent determinants of depression, together accounting for 12.4% of the variation of the BDI-21. The STAI-S index was significantly associated with the type of epilepsy syndrome (SFE). Finally, high seizure frequency, SFE and female gender were independent determinants of trait anxiety accounting for 14.7% of the variation of the STAI-T.
conclusionOur results confirm the prevailing view that depression and anxiety are common psychological disorders in epileptics. It is additionally concluded that female gender, high seizure frequency and a symptomatic epilepsy syndrome are independent risk factors for the development of anxiety and/or depression.
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