Trial reportSleep2007
The interactive effects of extended wakefulness and low-dose alcohol on simulated driving and vigilance.
Trial report in Sleep, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Discrepancy between self-reported intoxication and psychomotor vigilance task performance after alcohol intake: associations with BrAC, alcohol-metabolizing genotypes, and drinking tendency.Journal of physiological anthropology · 2026Article
- Theory-Based Determinants of Stopping Drowsy Driving Behavior in College Students: A Cross-Sectional Study.International journal of environmental research and public health · 2024Article
- Sleep and Alcohol Use Patterns During Federal Holidays and Daylight Saving Time Transitions in the United States.Frontiers in physiology · 2022Article
- Prolonged Eyelid Closure Episodes during Sleep Deprivation in Professional Drivers.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
- The Case for Addressing Operator Fatigue.Review of human factors and ergonomics · 2015Article
- Article
- Sensitivity and validity of psychometric tests for assessing driving impairment: effects of sleep deprivation.PloS one · 2015Article
- Drowsy driving and risk behaviors - 10 States and Puerto Rico, 2011-2012.MMWR. Morbidity and mortality weekly report · 2014Article
- Residual effects of zopiclone 7.5 mg on highway driving performance in insomnia patients and healthy controls: a placebo controlled crossover study.Psychopharmacology · 2014Article
- Insomnia and morning motor vehicle accidents: a decision analysis of the risk of hypnotics versus the risk of untreated insomnia.Journal of clinical psychopharmacology · 2014Article
- Alcohol calibration of tests measuring skills related to car driving.Psychopharmacology · 2014Article
- Interactions between age and moderate alcohol effects on simulated driving performance.Psychopharmacology · 2014Article
- The accuracy of eyelid movement parameters for drowsiness detection.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2013Article
- Driving simulator performance remains impaired in patients with severe OSA after CPAP treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2011Article
- Drowsiness/alertness algorithm development and validation using synchronized EEG and cognitive performance to individualize a generalized model.Biological psychology · 2011Article
- Medical and genetic differences in the adverse impact of sleep loss on performance: ethical considerations for the medical profession.Transactions of the American Clinical and Climatological Association · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesSleep deprivation and alcohol both impair driving performance. This study assessed the interactive effect of low-dose alcohol and extended wakefulness.
designRepeated-measures, crossover design evaluating psychomotor and driving function in a non-sleep-deprived state and after extended wakefulness with and without low-dose alcohol.
settingTeaching hospital sleep laboratory.
participantsNineteen volunteer professional drivers. INTERVENTION & MEASUREMENTS: Driving simulation (AusEd) and the Psychomotor Vigilance Task (PVT) were measured in a rested state (12-15 hours awake) and after extended wakefulness (18-21 hours awake) during two sessions. Alcohol was administered during one session, with performance measured at blood alcohol concentrations (BAC) of 0.00%, 0.03%, and 0.05% in a non-sleep-deprived state, and at 0.03% after extended wakefulness (at 01:00 and 03:00). During the second session, tests were performed at the same times without alcohol.
resultsThe combination of extended wakefulness and low-dose alcohol had significant deleterious effects on reaction time and lapses (PVT) and variation in lane position and speed (AusEd). Extended wakefulness (18-21 hours awake) combined with low-dose alcohol (0.03% BAC) resulted in more lapses (t = -2.75, P < 0.05) and greater variation in lane position (t = -3.94, P < 0.01) and speed (t = -2.79, P < 0.05) than did a BAC of 0.05% in a rested state.
conclusionThe combination of legal low-dose alcohol and extended wakefulness results in impairment worse than that at an alcohol level known to increase accident risk. Avoiding alcohol when driving after extended wakefulness may reduce accident risk.
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