SynthesisJournal of genetic counseling2008
How risk is perceived, constructed and interpreted by clients in clinical genetics, and the effects on decision making: systematic review.
Synthesis in Journal of genetic counseling, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Perceptions of risks for diabetes-related complications in Type 2 diabetes populations: a systematic review.Diabetic medicine : a journal of the British Diabetic Association · 2017Pooled it
- Effect of communicating personalized rheumatoid arthritis risk on concern for developing RA: A randomized controlled trial.Patient education and counseling · 2019Trial
- Lifestyle Advice Combined with Personalized Estimates of Genetic or Phenotypic Risk of Type 2 Diabetes, and Objectively Measured Physical Activity: A Randomized Controlled Trial.PLoS medicine · 2016Trial
- Cognitive and affective influences on perceived risk of ovarian cancer.Psycho-oncology · 2015Trial
- Impact of delivery models on understanding genomic risk for type 2 diabetes.Public health genomics · 2014Trial
- The effectiveness of a graphical presentation in addition to a frequency format in the context of familial breast cancer risk communication: a multicenter controlled trial.BMC medical informatics and decision making · 2013Trial
- Effect of communicating genetic and phenotypic risk for type 2 diabetes in combination with lifestyle advice on objectively measured physical activity: protocol of a randomised controlled trial.BMC public health · 2012Trial
- "I know what you told me, but this is what I think:" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate.Genetics in medicine : official journal of the American College of Medical Genetics · 2010Trial
- Can It Happen Again? Using Co-Produced Theatre to Explore the Challenges Faced by Couples Considering Pregnancy After a De Novo Genetic Diagnosis in a Child.Health expectations : an international journal of public participation in health care and health policy · 2026Article
- Facilitators and Barriers to Uptake of Genetic and Cascade Testing in Familial Hypercholesterolemia: a Systematic Review.International journal of behavioral medicine · 2026Article
- Providing recurrence risk counselling for parents after diagnosis of a serious genetic condition caused by an apparently de novo mutation in their child: a qualitative investigation of the PREGCARE strategy with UK clinical genetics practitioners.Journal of medical genetics · 2023Article
- Article
- Addressing the challenges of polygenic scores in human genetic research.American journal of human genetics · 2022Review
- Attitudes Toward Glaucoma Genetic Risk Assessment in Unaffected Individuals.Translational vision science & technology · 2022Article
- The Clinical and Psychosocial Outcomes for Women Who Received Unexpected Clinically Actionable Germline Information Identified through Research: An Exploratory Sequential Mixed-Methods Comparative Study.Journal of personalized medicine · 2022Article
- Women's awareness of ovarian cancer risk factors and symptoms in Western Iran in 2020-2021.BMC women's health · 2022Article
- Breast cancer polygenic risk scores: a 12-month prospective study of patient reported outcomes and risk management behavior.Genetics in medicine : official journal of the American College of Medical Genetics · 2021Article
- Challenges to effective and autonomous genetic testing and counseling for ethno-cultural minorities: a qualitative study.BMC medical ethics · 2020Article
- Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.Scientific reports · 2020Article
- Breast cancer risk, worry, and anxiety: Effect on patient perceptions of false-positive screening results.Breast (Edinburgh, Scotland) · 2020Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
As an individual's understanding of their genetic risk may influence risk management decisions, it is important to understand the ways in which risk is constructed and interpreted. We systematically reviewed the literature, undertaking a narrative synthesis of 59 studies presenting data on the ways in which individuals perceive, construct and interpret their risk, and the subsequent effects. While most studies assessed perceived risk quantitatively, the combined evidence suggests individuals find risk difficult to accurately quantify, with a tendency to overestimate. Rather than being a stand-alone concept, risk is something lived and experienced and the process of constructing risk is complex and influenced by many factors. While evidence of the effects of perceived risk is limited and inconsistent, there is some evidence to suggest high risk estimations may adversely affect health and lead to inappropriate uptake of medical surveillance and preventative measures by some individuals. A more focused approach to research is needed with greater exploration of the ways in which risk is constructed, along with the development of stronger theoretical models, to facilitate effective and patient-centered counseling strategies.
Indexed as
Identifiers
17968638What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.