ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2008
Cytotoxicity of human umbilical cord blood-derived mesenchymal stem cells against human malignant glioma cells.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Anti-oncogenic activities exhibited by paracrine factors of MSCs can be mediated by modulation ofMolecular therapy oncolytics · 2021Article
- Protective effects of human umbilical cord blood‑derived mesenchymal stem cells against dexamethasone‑induced apoptotic cell death in hair follicles.International journal of molecular medicine · 2020Article
- Tropism of mesenchymal stem cell toward CD133Stem cell research & therapy · 2018Article
- Inhibitory effect and molecular mechanism of mesenchymal stem cells on NSCLC cells.Molecular and cellular biochemistry · 2018Article
- Impact of mesenchymal stem cells' secretome on glioblastoma pathophysiology.Journal of translational medicine · 2017Article
- Conditioned Medium from Adipose-Derived Stem Cells (ADSCs) Promotes Epithelial-to-Mesenchymal-Like Transition (EMT-Like) in Glioma Cells In vitro.Molecular neurobiology · 2016Article
- Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP(5+), Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme.Stem cell reviews and reports · 2016Article
- Potential of Mesenchymal Stem Cell based application in Cancer.International journal of hematology-oncology and stem cell research · 2015Review
- Human umbilical cord mesenchymal stem cells inhibit C6 glioma growth via secretion of dickkopf-1 (DKK1).Molecular and cellular biochemistry · 2014Article
- Review
- Umbilical cord blood-derived mesenchymal stem cells inhibit, but adipose tissue-derived mesenchymal stem cells promote, glioblastoma multiforme proliferation.Stem cells and development · 2013Article
- Article
- Stem cells as therapeutic vehicles for the treatment of high-grade gliomas.Neuro-oncology · 2012Review
- Human amniotic membrane derived-mesenchymal stem cells induce C6 glioma apoptosis in vivo through the Bcl-2/caspase pathways.Molecular biology reports · 2012Article
- Identification and characterization of unique tumoricidal genes in rat umbilical cord matrix stem cells.Molecular pharmaceutics · 2011Article
- The role of stem cells in tumor targeting and growth suppression of gliomas.Biologics : targets & therapy · 2011Article
- Regenerative therapy after cancer: what are the risks?Tissue engineering. Part B, Reviews · 2010Review
- Cord blood stem cell-mediated induction of apoptosis in glioma downregulates X-linked inhibitor of apoptosis protein (XIAP).PloS one · 2010Article
- Article
- Induction of apoptosis in glioma cells requires cell-to-cell contact with human umbilical cord blood stem cells.International journal of oncology · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMesenchymal stem cells (MSCs) represent a potential useful source for cell-based glioma therapies because these cells evidence both orthodox and unorthodox plasticity and also show tropism for cancer. In this study, the authors attempted to access the cytotoxicity of human umbilical cord blood (hUCB)-derived MSCs, with or without cytokine activations against malignant glioma cells. MATERIALS AND
methodshUCB-derived MSCs were activated by interleukin-2, interleukin-15, granulocyte macrophage colony-stimulating factor, and combinations. The hUCB-derived MSCs and activated hUCB-derived MSCs were effector cells. The cytotoxicity of the unactivated hUCB-derived MSCs and activated hUCB-derived MSCs against the target cells (human malignant glioma cells) was estimated via visual survival cell assays and transwell inserts. Phenotypic changes occurring in these hUCB-derived MSCs before and after cytokine activation were determined via flow cytometry. The secreted proteins from these effector cells were estimated via enzyme-linked immunosorbent assays.
resultsWe noted a significant cytotoxicity of hUCB-derived MSCs against malignant glioma cells. In addition, the hUCB-derived MSCs activated with cytokines evidenced significantly higher cytotoxicity than that observed with unactivated hUCB-derived MSCs. Differentiated immune effectors cells from the hUCB-derived MSCs after cytokine activation were not shown to have increased in number. However, the activated hUCB-derived MSCs secreted more immune response-related proteins (interleukin 4, interferon-gamma) than did the unactivated hUCB-derived MSCs.
conclusionThe data collected herein confirm for the first time that hUCB-derived MSCs, with or without activation, evidence significant cytotoxicity against human malignant glioma cells, and the immune response-related proteins secreted in this process may perform relevant functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.