ArticleRheumatology international2008
Leptin serum levels in rheumatoid arthritis patients: relation to disease duration and activity.
Article in Rheumatology international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Pooled it
- Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis.Irish journal of medical science · 2014Pooled it
- Emerging role of leptin in rheumatoid arthritis.Clinical and experimental immunology · 2014Pooled it
- The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases.Biomedicines · 2023Review
- Effect of resistance exercise on serum leptin levels in a prospective longitudinal study of women patients with rheumatoid arthritis.Arthritis research & therapy · 2022Article
- Leptin in Osteoarthritis and Rheumatoid Arthritis: Player or Bystander?International journal of molecular sciences · 2022Review
- Hypoxia Inhibits Osteogenesis and Promotes Adipogenesis of Fibroblast-like Synoviocytes via Upregulation of Leptin in Patients with Rheumatoid Arthritis.Journal of immunology research · 2022Article
- Adipokines and periodontal markers as risk indicators of early rheumatoid arthritis: a cross-sectional study.Clinical oral investigations · 2021Article
- The complex role of adipokines in obesity, inflammation, and autoimmunity.Clinical science (London, England : 1979) · 2021Review
- Role of Leptin in Inflammation and Vice Versa.International journal of molecular sciences · 2020Review
- Clinical associations of serum leptin and leptin/adiponectin ratio in systemic sclerosis.Postepy dermatologii i alergologii · 2019Article
- Leptin is associated with disease activity but not with anthropometric indices in rheumatoid arthritis patients.Archives of medical science : AMS · 2018Article
- Article
- Obesity, Fat Mass and Immune System: Role for Leptin.Frontiers in physiology · 2018Review
- Serum levels of adipokines in patients with idiopathic inflammatory myopathies: a pilot study.Rheumatology international · 2017Article
- Leptin in the interplay of inflammation, metabolism and immune system disorders.Nature reviews. Rheumatology · 2017Review
- Relationship Between Leptin and Neopterin Levels and Disease Activation Parameters in Patients With Rheumatoid Arthritis.Archives of rheumatology · 2016Article
- Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies.Arthritis research & therapy · 2015Article
- Roles of leptin in bone metabolism and bone diseases.Journal of bone and mineral metabolism · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leptin is a peptide hormone with the tertiary structure of a cytokine, which not only regulates body weight by inhibiting food intake, but also modulates inflammatory and immune responses. The aim of the study was to investigate if there are connections between leptin concentrations and parameters of nutritional status and disease activity in a group of rheumatoid arthritis (RA) patients. The study group consisted of 37 patients. The mean leptin serum concentration was significantly higher in women than in men. The leptin concentrations correlated positively with BMI only in women with RA. The leptin concentrations were significantly higher in patients with erosive RA. Assessing the group of patients with long-standing RA (duration > 10 years), we found that leptin levels were significantly higher in patients with higher disease activity than in those with DAS28 < or = 5,1; there was also a positive correlation between serum leptin concentration and the value of DAS28, ESR and the number of tender joints. The results suggest that some important dependence exists between the risk of aggressive course of RA and increased leptin levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.