ArticleJournal of bone and mineral metabolism2007
A histological assessment on the distribution of the osteocytic lacunar canalicular system using silver staining.
Article in Journal of bone and mineral metabolism, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Preclinical Rodent Models for Human Bone Disease, Including a Focus on Cortical Bone.Endocrine reviews · 2024Review
- Bundling of collagen fibrils influences osteocyte network formation during bone modeling.Scientific reports · 2023Article
- Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone: A pilot study.Bioactive materials · 2023Article
- Micron-resolution Imaging of Cortical Bone under 14 T Ultrahigh Magnetic Field.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Uniaxially fixed mechanical boundary condition elicits cellular alignment in collagen matrix with induction of osteogenesis.Scientific reports · 2021Article
- Immunocytochemical assessment of cell differentiation of podoplanin-positive osteoblasts into osteocytes in murine bone.Histochemistry and cell biology · 2021Article
- Osteocytic Osteolysis in PTH-treated Wild-type andThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Three-dimensional ultrastructure of osteocytes assessed by focused ion beam-scanning electron microscopy (FIB-SEM).Histochemistry and cell biology · 2018Article
- Lacunar-canalicular network in femoral cortical bone is reduced in aged women and is predominantly due to a loss of canalicular porosity.Bone reports · 2017Article
- Aging, Osteocytes, and Mechanotransduction.Current osteoporosis reports · 2017Review
- Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis.Bone · 2016Article
- Impact of Non-Invasively Induced Motor Deficits on Tibial Cortical Properties in Mutant Lurcher Mice.PloS one · 2016Article
- Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network.PloS one · 2015Article
- Characteristics of alveolar bone associated with physiological movement of molar in mice: a histological and histochemical study.Odontology · 2014Article
- The cast imaging of the osteon lacunar-canalicular system and the implications with functional models of intracanalicular flow.Journal of anatomy · 2013Article
- Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates.Journal of bone and mineral metabolism · 2011Article
- Nanoscale X-ray microscopic imaging of mammalian mineralized tissue.Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada · 2010Article
- Attachment of osteocyte cell processes to the bone matrix.Anatomical record (Hoboken, N.J. : 2007) · 2009Article
- Specialized connective tissue: bone, the structural framework of the upper extremity.Journal of hand therapy : official journal of the American Society of Hand TherapistsArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giving the complexity that characterizes the mechanisms of bone remodeling and the number of events that have to be in absolute harmony for it to occur flawlessly, the postulation that temporospatial distribution of osteocytes and their lacunar canalicular system might influence and be influenced by bone remodeling can be regarded, at least, as feasible. In this study, using Schoen's silver staining, we have examined the distribution of the osteocytic lacunar canalicular system (OLCS) in bones of developing mice. Trabecular bones of 3-day-old, 2-week-old, and 3-week-old mice displayed osteocytic cytoplasmic processes without any perceptible alignment. Also, many plump osteocytes were embedded in the mineralized bone matrix in a disorderly manner. At 4 weeks of age, however, mice bones showed some osteocytic processes that reached the bone surface on a right angle, while other osteocytes displayed the same features seen on 3-week specimens. Samples at 8 weeks of age featured osteocytes with their usual spindle shape, organized so as to parallel the longitudinal axis of trabecular bone. They also extended their cytoplasmic processes perpendicularly to the bone surface. However, several osteocytes immersed in older bone, i.e., a residual mix of cartilage and bone matrices, still showed a random pattern of distribution of their cytoplasmic processes. Up to 12 weeks of age, the majority of the osteocytes became flattened and were shown to be aligned with their long axis paralleling the bone surface. This tendency for such a gradual arrangement was also observed in cortical bones. We have further demonstrated that 8-week-old osteoprotegerin-deficient mice, which demonstrated histological evidence of higher than average bone turnover, revealed a disorganized OLCS. Given the data gathered in this work, the OLCS appears to assume an organized, probably function-related spatial distribution as normal bone remodeling goes on.
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Registered trials
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