ArticleOncogene2008
Microarray analysis refines classification of non-medullary thyroid tumours of uncertain malignancy.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- An in-depth study of the correlation between Hashimoto's thyroiditis and Sjogren's syndrome: multiple evidences from large cohorts, Mendelian randomization, and transcriptomic analysis.European journal of epidemiology · 2026Article
- Systems biology approach delineates critical pathways associated with papillary thyroid cancer: a multi-omics data analysis.Thyroid research · 2025Article
- Identification of GPX3 and JUN as Tumor Suppressors in Thyroid Cancer through Integrated WGCNA and Mendelian Randomization.Journal of Cancer · 2025Article
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- Downregulation of miR‑193a‑3p via targeting cyclin D1 in thyroid cancer.Molecular medicine reports · 2020Article
- Aging-associated genesOncology letters · 2020Article
- Clinical Significance and Potential Regulatory Mechanisms of Serum Response Factor in 1118 Cases of Thyroid Cancer Based on Gene Chip and RNA-Sequencing Data.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Genetic expression profile-based screening of genes and pathways associated with papillary thyroid carcinoma.Oncology letters · 2018Article
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- QiSampler: evaluation of scoring schemes for high-throughput datasets using a repetitive sampling strategy on gold standards.BMC research notes · 2011Article
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- Increasing the number of thyroid lesions classes in microarray analysis improves the relevance of diagnostic markers.PloS one · 2009Article
- Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours.British journal of cancer · 2009Article
- Thyroid tumours of uncertain malignant potential: frequency and diagnostic reproducibility.Virchows Archiv : an international journal of pathology · 2009Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional histology failed to classify part of non-medullary thyroid lesions as either benign or malignant. The group of tumours of uncertain malignancy (T-UM) concerns either atypical follicular adenomas or the recently called 'tumours of uncertain malignant potential'. To refine this classification we analysed microarray data from 93 follicular thyroid tumours: 10 T-UM, 3 follicular carcinomas, 13 papillary thyroid carcinomas and 67 follicular adenomas, compared to 73 control thyroid tissue samples. The diagnosis potential of 16 selected genes was validated by real-time quantitative RT-PCR on 6 additional T-UM. The gene expression profiles in several groups were examined with reference to the mutational status of the RET/PTC, BRAF and RAS genes. A pathological score (histological and immunohistochemical) was estimate for each of the T-UM involved in the study. The correlation between the T-UM gene profiles and the pathological score allowed a separation of the samples in two groups of benign or malignant tumours. Our analysis confirms the heterogeneity of T-UM and highlighted the molecular similarities between some cases and true carcinomas. We demonstrated the ability of few marker genes to serve as diagnosis tools and the need of a T-UM pathological scoring.
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