ArticleOncogene2008
Immortalization of epithelial progenitor cells mediated by resveratrol.
Article in Oncogene, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: a crossover randomized clinical trial.The American journal of clinical nutrition · 2019Trial
- Sirtuins and redox signaling interplay in neurogenesis, neurodegenerative diseases, and neural cell reprogramming.Frontiers in neuroscience · 2023Review
- Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging.International journal of molecular sciences · 2021Review
- Potential of Naturally Derived Compounds in Telomerase and Telomere Modulation in Skin Senescence and Aging.International journal of molecular sciences · 2021Review
- Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy.International journal of molecular sciences · 2018Review
- Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice.Theranostics · 2018Article
- Ascorbic Acid Attenuates Senescence of Human Osteoarthritic Osteoblasts.International journal of molecular sciences · 2017Article
- Management of suspected monogenic lung fibrosis in a specialised centre.European respiratory review : an official journal of the European Respiratory Society · 2017Review
- Tissue Distribution ofJournal of ophthalmology · 2017Article
- Therapeutic Targeting of Telomerase.Genes · 2016Review
- Chemical and Physical Approaches to Extend the Replicative and Differentiation Potential of Stem Cells.Stem cell reviews and reports · 2016Review
- Effects of resveratrol on the proliferation, apoptosis and telomerase ability of human A431 epidermoid carcinoma cells.Oncology letters · 2016Article
- Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms.Frontiers in genetics · 2016Review
- Disruptive chemicals, senescence and immortality.Carcinogenesis · 2015Review
- Up-regulating telomerase and tumor suppressors: focusing on anti-aging interventions at the population level.Aging and disease · 2014Review
- The journey of resveratrol from yeast to human.Aging · 2012Review
- Challenges of translating basic research into therapeutics: resveratrol as an example.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Pharmaceutical regulation of telomerase and its clinical potential.Journal of cellular and molecular medicine · 2012Review
- Medical genetics and epigenetics of telomerase.Journal of cellular and molecular medicine · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Within the hierarchy of epithelial stem cells, normal progenitor cells may express regulated telomerase during renewal cycles of proliferation and differentiation. Discontinuous telomerase activity may promote increased renewal capacity of progenitor cells, while deregulated/continuous telomerase activity may promote immortalization when differentiation and/or senescent pathways are compromised. In the present work, we show that resveratrol activates, while progesterone inactivates, continuous telomerase activity within 24 h in subpopulations of human Li-Fraumeni syndrome-derived breast epithelial cells. Resveratrol results in immortalization of mixed progenitor cells with mutant p53, but not human epithelial cells with wild type p53. Our results demonstrate the potential for renewing progenitor cells with mutant p53 to immortalize after continuous telomerase expression when exposed to certain environmental compounds. Understanding the effects of telomerase modulators on endogenous telomerase activity in progenitor cells is relevant to the role of immortalization in the initiation and progression of cancer subtypes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.