ArticleMolecular and cellular biology2008
Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Article in Molecular and cellular biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Mom genes and dad genes: genomic imprinting in the regulation of social behaviors.Epigenomics · 2025Review
- Cardiac Roles of Serotonin (5-HT) and 5-HT-Receptors in Health and Disease.International journal of molecular sciences · 2023Review
- Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.Molecular cell · 2022Article
- Noncanonical genomic imprinting in the monoamine system determines naturalistic foraging and brain-adrenal axis functions.Cell reports · 2022Article
- A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain.Frontiers in cell and developmental biology · 2022Article
- Review
- DNA methylation abnormalities of imprinted genes in congenital heart disease: a pilot study.BMC medical genomics · 2021Article
- Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.Frontiers in cell and developmental biology · 2021Article
- Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing.Developmental cell · 2020Article
- Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.Environmental epigenetics · 2017Article
- Alternative promoters of Peg3 with maternal specificity.Scientific reports · 2016Article
- Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain.eLife · 2015Article
- Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome.Genetics · 2015Article
- Known unknowns for allele-specific expression and genomic imprinting effects.F1000prime reports · 2014Review
- Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop.Nucleic acids research · 2013Article
- Selected imprinting of INS in the marsupial.Epigenetics & chromatin · 2012Article
- A survey of tissue-specific genomic imprinting in mammals.Molecular genetics and genomics : MGG · 2012Review
- Critical evaluation of imprinted gene expression by RNA-Seq: a new perspective.PLoS genetics · 2012Article
- Characterization of conserved and nonconserved imprinted genes in swine.Biology of reproduction · 2009Article
- Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
By combining a tissue-specific microarray screen with mouse uniparental duplications, we have identified a novel imprinted gene, Dopa decarboxylase (Ddc), on chromosome 11. Ddc_exon1a is a 2-kb transcript variant that initiates from an alternative first exon in intron 1 of the canonical Ddc transcript and is paternally expressed in trabecular cardiomyocytes of the embryonic and neonatal heart. Ddc displays tight conserved linkage with the maternally expressed and methylated Grb10 gene, suggesting that these reciprocally imprinted genes may be coordinately regulated. In Dnmt3L mutant embryos that lack maternal germ line methylation imprints, we show that Ddc is overexpressed and Grb10 is silenced. Their imprinting is therefore dependent on maternal germ line methylation, but the mechanism at Ddc does not appear to involve differential methylation of the Ddc_exon1a promoter region and may instead be provided by the oocyte mark at Grb10. Our analysis of Ddc redefines the imprinted Grb10 domain on mouse proximal chromosome 11 and identifies Ddc_exon1a as the first example of a heart-specific imprinted gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.