ArticleNeurotoxicity research2007
Effects of pituitary adenylate cyclase activating polypeptide (PACAP) on the PKA-Bad-14-3-3 signaling pathway in glutamate-induced retinal injury in neonatal rats.
Article in Neurotoxicity research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- The Protective Effects of Endogenous PACAP in Oxygen-Induced Retinopathy.Journal of molecular neuroscience : MN · 2021Article
- PACAP and NAP: Effect of Two Functionally Related Peptides in Diabetic Retinopathy.Journal of molecular neuroscience : MN · 2021Review
- Neuroprotective Potential of Pituitary Adenylate Cyclase Activating Polypeptide in Retinal Degenerations of Metabolic Origin.Frontiers in neuroscience · 2019Review
- Article
- Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents.International journal of molecular sciences · 2017Article
- Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Against Oxidative Stress in Zebrafish Hair Cells.Neurotoxicity research · 2016Article
- Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Signal via Phospholipase C Pathway to Block Apoptosis in Newborn Rat Retina.Neurochemical research · 2015Article
- Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.Journal of neurochemistry · 2014Article
- Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells.The Journal of biological chemistry · 2014Article
- Role of mitochondrial activation in PACAP dependent neurite outgrowth.Journal of molecular neuroscience : MN · 2012Article
- Effects of PACAP on intracellular signaling pathways in human retinal pigment epithelial cells exposed to oxidative stress.Journal of molecular neuroscience : MN · 2012Article
- Mice deficient in pituitary adenylate cyclase activating polypeptide (PACAP) are more susceptible to retinal ischemic injury in vivo.Neurotoxicity research · 2012Article
- Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.Journal of molecular neuroscience : MN · 2011Article
- Effects of PACAP in UV-A radiation-induced retinal degeneration models in rats.Journal of molecular neuroscience : MN · 2011Article
- PACAP improves functional outcome in excitotoxic retinal lesion: an electroretinographic study.Journal of molecular neuroscience : MN · 2011Article
- Pituitary adenylate cyclase-activating polypeptide is protective against oxidative stress in human retinal pigment epithelial cells.Journal of molecular neuroscience : MN · 2011Article
- Protective effects of edaravone on diffuse brain injury in rats.World journal of emergency medicine · 2011Article
- Protective effect of PACAP against doxorubicin-induced cell death in cardiomyocyte culture.Journal of molecular neuroscience : MN · 2010Article
- Novel neuroprotective strategies in ischemic retinal lesions.International journal of molecular sciences · 2010Review
- Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases.Neurotoxicity research · 2009Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuropeptide PACAP (pituitary adenylate cyclase activating polypeptide) and its receptors are widely expressed in the nervous system including the retina. PACAP has well-known neuroprotective effects in neuronal cultures in vitro and against different insults in vivo. Recently, we have shown that PACAP1-38 is neuroprotective against monosodium glutamate (MSG)-induced retinal degeneration. Studying the molecular mechanisms of this protection has revealed that PACAP1-38 stimulates anti-apoptotic mechanisms such as phosphorylation of ERK1/2 and inhibits pro-apoptotic signaling molecules such as JNK1/2, p38MAPK, caspase-3 and the translocation of mitochondrial cytochrome c and apoptosis inducing factor in glutamate-treated retinas in vivo. In the present study we investigated the effects of PACAP1-38 on a further signal transduction pathway possibly involved in the protective effect of intravitreal PACAP1-38 administration against apoptotic retinal degeneration induced by neonatal MSG treatment. The focus of the present study was the protein kinase A (PKA)-Bad-14-3-3 transduction pathway. In vivo MSG treatment led to a reduction in the levels of anti-apoptotic molecules (phospho-PKA phospho-Bad, Bcl-xL and 14-3-3 proteins) in the retina. Co-treatment with PACAP1-38 counteracted these effects: the level of phospho-PKA, phospho-Bad, Bcl-xL and 14-3-3 were increased. All effects of PACAP1-38 were inhibited by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP1-38 activates the PKA-Bad-14-3-3 pathway which is inhibited by MSG treatment. Our results also provide new insights into the signaling mechanisms possibly involved in the PACAP-mediated anti-apoptotic effects.
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