ArticleInternational journal of radiation oncology, biology, physics2007
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.
Article in International journal of radiation oncology, biology, physics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 52 citations in OpenAlex.
- Biodistribution and dosimetry of (18)F-EF5 in cancer patients with preliminary comparison of (18)F-EF5 uptake versus EF5 binding in human glioblastoma.European journal of nuclear medicine and molecular imaging · 2010Trial
- Hypoxia-informed RBE-weighted beam orientation optimization for intensity modulated proton therapy.Medical physics · 2024Article
- Hypoxia regulates the differentiation and anti-tumor effector functions of γδT cells in oral cancer.Clinical and experimental immunology · 2020Article
- Radiotherapy and the cellular DNA damage response: current and future perspectives on head and neck cancer treatment.Cancer drug resistance (Alhambra, Calif.) · 2020Review
- Invited editorial for the paper by Silvoniemi et al. "Repeatability of tumor hypoxia imaging using [European journal of nuclear medicine and molecular imaging · 2018Article
- Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids.Journal of experimental & clinical cancer research : CR · 2017Review
- Prediction of the treatment outcome using intravoxel incoherent motion and diffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients.European radiology · 2017Article
- Molecular mechanisms of hypoxia in cancer.Clinical and translational imaging · 2017Review
- Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity.Cold Spring Harbor perspectives in medicine · 2016Review
- Development of a mathematical model to estimate intra-tumor oxygen concentrations through multi-parametric imaging.Biomedical engineering online · 2016Article
- Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Head and Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and Early Treatment Period.AJNR. American journal of neuroradiology · 2016Article
- The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.Antioxidants & redox signaling · 2014Review
- Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2014Article
- p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice.Science signaling · 2012Article
- Hypoxia and fetal heart development.Current molecular medicine · 2010Review
- The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study.Translational oncology · 2010Article
- Theory, instrumentation, and applications of electron paramagnetic resonance oximetry.Chemical reviews · 2010Review
- Contribution of hypoxia-measuring molecular imaging techniques to radiotherapy planning and treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Review
- Imaging and analytical methods as applied to the evaluation of vasculature and hypoxia in human brain tumors.Radiation research · 2008Article
- Molecular aspects of tumour hypoxia.Molecular oncology · 2008Review
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10 authors at 1 institution in 1 country.
Funding
Abstract
purposeEF5, a 2-nitroimidazole hypoxia marker, was used to study the presence, levels, and prognostic significance of hypoxia in primary head and neck squamous cell tumors. METHODS AND MATERIALS: Twenty-two patients with newly diagnosed squamous cell carcinoma of the oral cavity, oropharynx, or larynx with at least 2 years of clinical follow-up were included in this study. Quantitative analyses of EF5 immunofluorescence was carried out, and these data were compared with patient outcome.
resultsEF5 immunostaining showed substantial intra- and intertumoral hypoxic heterogeneity. The majority of cells in all tumors were well oxygenated. Three patterns of EF5 binding in cells were identified using criteria based on the cellular region that was stained (peripheral or central) and the relationship of binding to necrosis. We tested the association between EF5-binding levels with event-free and overall survival irrespective of the pattern of cellular binding or treatment regimen. Patients with tumors containing EF5-binding regions corresponding to severe hypoxia (< or =0.1% oxygen) had a shorter event-free survival time than patients with pO(2) values greater than 0.1% (p = 0.032). Nodal status was also predictive for outcome.
conclusionsThese data illustrate the potential utility of EF5 binding based on quantitative immunohistochemistry of tissue pO(2) and provide support for the development of noninvasive hypoxia positron emission tomographic studies with fluorine 18-labeled EF5.
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