ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2008
Relationships between fat and bone.
Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of body mass index and bone mineral density in postmenopausal women: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies.European journal of epidemiology · 2012 · on this mapPooled it
- Greater inflammation and adiposity are associated with lower bone mineral density in youth with type 1 diabetes.Diabetes research and clinical practice · 2018Trial
- Soft tissues, areal bone mineral density and hip geometry estimates in active young boys: the PRO-BONE study.European journal of applied physiology · 2017Trial
- A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women.Nutrition journal · 2012Trial
- Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial.Diabetes care · 2012Trial
- Physical training increases osteoprotegerin in postmenopausal women.Journal of bone and mineral metabolism · 2012Trial
- Effect of 1 year of an intentional weight loss intervention on bone mineral density in type 2 diabetes: results from the Look AHEAD randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Trial
- Changes in total body bone mineral density following a common bone health plan with two versions of a unique bone health supplement: a comparative effectiveness research study.Nutrition journal · 2011Trial
- Long-term body composition changes after bariatric surgery and their association with fat- and bone-derived hormones.Endocrine · 2026Observational
- Development and internal validation of a clinical-radiological nomogram for osteoporosis screening: A cohort retrospective study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Association Between Waist-to-Height Ratio Estimated Fat Mass Categories and Incident Fractures.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association between Body Composition Characteristics and Bone Mineral Density across Menopausal Transition Stages.Journal of menopausal medicine · 2025Article
- The obesity paradox in osteoporosis risk among older adults is mostly driven by women: a population-based prospective study.BMC geriatrics · 2025Article
- Analysis of changes in bone mineral density and cortical bone thickness after reconstruction of the mandible with fibula, is condyle preservation a critical influence factor?Clinical oral investigations · 2024Article
- Article
- Prevalence and associated factors of low bone mineral density in people living with HIV: a cross-sectional study.Archives of osteoporosis · 2024Article
- Association of bone fracture with 30-year body mass index (BMI) trajectories: findings from the Framingham Heart Study : Bone fracture and 30-year BMI trajectories.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Constructing and validating a predictive nomogram for osteoporosis risk among Chinese single-center male population using the systemic immune-inflammation index.Scientific reports · 2024Article
- The Monocyte-to-High-Density Lipoprotein Cholesterol Ratio as a Novel Predictor of the Prevalence of Senile Osteoporosis.Clinical interventions in aging · 2024Article
126 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body weight impacts both bone turnover and bone density, making it, therefore, an important risk factor for vertebral and hip fractures and ranking it alongside age in importance. The effect of body weight is probably contributed to by both fat mass and lean mass, though in postmenopausal women, fat mass has been more consistently demonstrated to be important. A number of mechanisms for the fat-bone relationship exist and include the effect of soft tissue mass on skeletal loading, the association of fat mass with the secretion of bone active hormones from the pancreatic beta cell (including insulin, amylin, and preptin), and the secretion of bone active hormones (e.g., estrogens and leptin) from the adipocyte. These factors alone probably do not fully explain the observed clinical associations, and study of the actions on bone of novel hormones related to nutrition is an important area of further research. An understanding of this aspect of bone biology may open the way for new treatments of osteoporosis. More immediately, the role of weight maintenance in the prevention of osteoporosis is an important public health message that needs to be more widely appreciated.
Indexed as
Identifiers
17965817What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.