ArticleEvidence-based complementary and alternative medicine : eCAM2007
Indigofera suffruticosa: an alternative anticancer therapy.
Article in Evidence-based complementary and alternative medicine : eCAM, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Review
- Article
- Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells.Oncotarget · 2015Article
- Antineoplasic effect of aqueous extract of plectranthus amboinicus in ehrlich ascites carcinoma.Journal of Cancer · 2013Article
- Oviposition and Embryotoxicity of Indigofera suffruticosa on Early Development of Aedes aegypti (Diptera: Culicidae).Evidence-based complementary and alternative medicine : eCAM · 2012Article
- An agonist sensitive, quick and simple cell-based signaling assay for determination of ligands mimicking prostaglandin E2 or E1 activity through subtype EP1 receptor: Suitable for high throughput screening.BMC complementary and alternative medicine · 2011Article
- Antimetastatic Potentials of Dioscorea nipponica on Melanoma In Vitro and In Vivo.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Nordihydroguaiaretic Acid from Creosote Bush (Larrea tridentata) Mitigates 12-O-Tetradecanoylphorbol-13-Acetate-Induced Inflammatory and Oxidative Stress Responses of Tumor Promotion Cascade in Mouse Skin.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Predictive analyses of biological effects of natural products: from plant extracts to biomolecular laboratory and computer modeling.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Mutagenic Activity of Indigofera truxillensis and I. suffruticosa Aerial Parts.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Inhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous cell Carcinoma by Genistein and Biochanin A.Evidence-based complementary and alternative medicine : eCAM · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indigofera suffruticosa Mill (Fabeceae) occurs in the Northeast countryside and has intensive popular use in the treatment of infectious, inflammatory and other processes. The main aim of the present work was to investigate the cytotoxic and antitumor effects of aqueous extracts of leaves of I. suffruticosa obtained by infusion and maceration as well as to evaluate the toxicological properties. Aqueous extracts did not exhibit cytotoxicity against HEp-2 (human epidermoid cancer cell) cell lines by MTT method. From the aqueous extract by infusion, the toxicological assay showed low order of toxicity. The antitumor effect of aqueous extracts by infusion (64.53%) and maceration (62.62%) against sarcoma 180 in mice at a dose of 50 mg kg(-1) (intraperitoneally), based on low order of toxicity was comparable to the control group, which showed 100% development. Considering the low order of toxicity and that it is highly effective in inhibiting growth of solid tumors, the aqueous extracts of leaves of I. suffruticosa may be used as an alternative anticancer agent.
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Registered trials
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