ArticleEpigenetics
Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake.
Article in Epigenetics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Trial
- The Effects of Dietary Interventions on DNA Methylation: Implications for Obesity Management.International journal of molecular sciences · 2020Review
- DNA methylation-based variation between human populations.Molecular genetics and genomics : MGG · 2017Review
- Biomarkers of Nutrition for Development-Folate Review.The Journal of nutrition · 2015Review
- Racial differences in IGF1 methylation and birth weight.Clinical epigenetics · 2015Article
- Epigenomic association analysis identifies smoking-related DNA methylation sites in African Americans.Human genetics · 2013Article
- Social factors and leukocyte DNA methylation of repetitive sequences: the multi-ethnic study of atherosclerosis.PloS one · 2013Article
- Micronutrient status and global DNA methylation in school-age children.Epigenetics · 2012Article
- DNA methylation in white blood cells: association with risk factors in epidemiologic studies.Epigenetics · 2011Review
- Dietary patterns are associated with levels of global genomic DNA methylation in a cancer-free population.The Journal of nutrition · 2011Article
- Global methylation profiles in DNA from different blood cell types.Epigenetics · 2011Article
- Quantification of leukocyte genomic 5-methylcytosine levels reveals epigenetic plasticity in healthy adult cloned cattle.Cellular reprogramming · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
DNA methylation is an epigenetic feature that may modify disease risk, and can be influenced by folate status as well as by methylenetetrahydrofolate reductase (MTHFR) C677T genotype. The aim of this study was to investigate the influence of ethnicity/race on global leukocyte DNA methylation under conditions of controlled folate intake. Caucasian (n = 14) and African American (n = 14) women (18 - 45 y) possessing the MTHFR 677CC genotype consumed a folate restricted diet (135 mug/d as dietary folate equivalents, DFE) for 7 week followed by folate treatment with 400 or 800 microg DFE/d for 7 week. Global leukocyte DNA methylation was assessed via the cytosine extension assay at baseline (wk 0), after folate restriction (wk 7) and after folate treatment (wk 14). Ethnicity/race was not a determinant of global leukocyte DNA methylation. No differences (p > 0.05) were detected in DNA methylation between African American and Caucasian women at baseline or any other study time point. In addition, folate intake did not modify global leukocyte DNA methylation. These data suggest that global leukocyte DNA methylation does not differ between Caucasian and African American women and that short-term folate restriction is not sufficient to modify methylation content in young women with the MTHFR 677CC genotype.
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