ArticleThe Plant cell2007
MPB2C, a microtubule-associated protein, regulates non-cell-autonomy of the homeodomain protein KNOTTED1.
Article in The Plant cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 69 citations in OpenAlex.
- Cellular Partners of Tobamoviral Movement Proteins.International journal of molecular sciences · 2025Review
- Rewiring of a KNOXI regulatory network mediated by UFO underlies the compound leaf development in Medicago truncatula.Nature communications · 2024Article
- Distributing Plant Developmental Regulatory Proteins via Plasmodesmata.Plants (Basel, Switzerland) · 2024Review
- Stem Cells: Engines of Plant Growth and Development.International journal of molecular sciences · 2023Review
- SKI-INTERACTING PROTEIN interacts with SHOOT MERISTEMLESS to regulate shoot apical meristem formation.Plant physiology · 2022Article
- A coiled-coil protein associates Polycomb Repressive Complex 2 with KNOX/BELL transcription factors to maintain silencing of cell differentiation-promoting genes in the shoot apex.The Plant cell · 2022Article
- Trafficking and localization ofCommunicative & integrative biology · 2022Article
- Micromorphology, Ultrastructure and Histochemistry ofPlants (Basel, Switzerland) · 2021Article
- The regulatory mechanism of chilling-induced dormancy transition from endo-dormancy to non-dormancy in Polygonatum kingianum Coll.et Hemsl rhizome bud.Plant molecular biology · 2019Article
- KinG Is a Plant-Specific Kinesin That Regulates Both Intra- and Intercellular Movement of SHORT-ROOT.Plant physiology · 2018Article
- Article
- ALTERED MERISTEM PROGRAM1 suppresses ectopic stem cell niche formation in the shoot apical meristem in a largely cytokinin-independent manner.Plant physiology · 2015Article
- Transcriptional, posttranscriptional, and posttranslational regulation of SHOOT MERISTEMLESS gene expression in Arabidopsis determines gene function in the shoot apex.Plant physiology · 2015Article
- Cell-to-cell movement of viruses via plasmodesmata.Journal of plant research · 2015Review
- Identification of evolutionarily conserved amino acid residues in homeodomain of KNOX proteins for intercellular trafficking.Plant signaling & behavior · 2014Article
- TALE and Shape: How to Make a Leaf Different.Plants (Basel, Switzerland) · 2013Review
- The chaperonin CCT8 facilitates spread of tobamovirus infection.Plant signaling & behavior · 2012Article
- RNA transport during TMV cell-to-cell movement.Frontiers in plant science · 2012Article
- Cellular pathways for viral transport through plasmodesmata.Protoplasma · 2011Review
- Microtubule-associated protein AtMPB2C plays a role in organization of cortical microtubules, stomata patterning, and tobamovirus infectivity.Plant physiology · 2009Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasmodesmata establish a pathway for the intercellular trafficking of viral movement proteins and endogenous non-cell-autonomous proteins, such as the two closely related meristem-maintaining KNOTTED1-like homeobox (KNOX) proteins Zea mays KNOTTED1 (KN1) and Arabidopsis thaliana SHOOTMERISTEMLESS (STM). KNOX family members are DNA binding proteins that regulate the transcriptional activity of target genes in conjunction with BEL1-like homeodomain proteins. It has been shown previously, using in vivo transport assays, that the C-terminal domain of KN1, including the homeodomain, is necessary and sufficient for cell-to-cell transport through plasmodesmata. Here, using interaction and coexpression assays, we demonstrate that the microtubule-associated and viral movement protein binding protein MPB2C from Nicotiana tabacum, and its homolog in Arabidopsis, At MPB2C, are KN1/STM binding factors. Interaction between the MPB2C proteins and KN1/STM was mapped to the KN1 homeodomain, a region not essential for heterodimerization with BEL1. Expression of MPB2C in single cells prevented KN1 cell-to-cell movement. Furthermore, in vivo trichome rescue studies established that MPB2C negatively regulates KN1 association to plasmodesmata and, consequently, cell-to-cell transport. These findings are discussed in terms of the role played by MPB2C proteins in regulating the cell-to-cell trafficking of homeodomain proteins in plants.
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