ArticleJournal of bacteriology2008
The metalloprotease of Listeria monocytogenes is activated by intramolecular autocatalysis.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Toad's survivability and soil microbiome alterations impacted via individual abundance.Biologia futura · 2025Article
- Insight into the role of Streptococcus suis zinc metalloprotease C from the new serotype causing meningitis in piglets.BMC veterinary research · 2024Article
- Genomic and pathogenicity islands ofFrontiers in molecular biosciences · 2023Review
- Bacteria-mediated cancer therapy: A versatile bio-sapper with translational potential.Frontiers in oncology · 2022Review
- Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center.BMC molecular and cell biology · 2021Article
- An M29 Aminopeptidase fromMicroorganisms · 2020Article
- Review
- The Metalloprotease Mpl Supports Listeria monocytogenes Dissemination through Resolution of Membrane Protrusions into Vacuoles.Infection and immunity · 2016Article
- Identification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles.PLoS pathogens · 2015Article
- Proteolytic Activities Expressed by Gastrointestinal PathogensBritish microbiology research journal · 2015Article
- A non-catalytic histidine residue influences the function of the metalloprotease of Listeria monocytogenes.Microbiology (Reading, England) · 2014Article
- Protein transport across the cell wall of monoderm Gram-positive bacteria.Molecular microbiology · 2012Review
- Activation and proteolytic activity of the Treponema pallidum metalloprotease, pallilysin.PLoS pathogens · 2012Article
- Posttranslocation chaperone PrsA2 regulates the maturation and secretion of Listeria monocytogenes proprotein virulence factors.Journal of bacteriology · 2011Article
- A novel C-terminal mutation resulting in constitutive activation of the Listeria monocytogenes central virulence regulatory factor PrfA.Microbiology (Reading, England) · 2011Article
- The metalloprotease of Listeria monocytogenes is regulated by pH.Journal of bacteriology · 2011Article
- Bifunctional role of the Treponema pallidum extracellular matrix binding adhesin Tp0751.Infection and immunity · 2011Article
- Probing the role of protein surface charge in the activation of PrfA, the central regulator of Listeria monocytogenes pathogenesis.PloS one · 2011Article
- Listeria endocarditis in a patient with psoriatic arthritis on infliximab: are biologic agents as treatment for inflammatory arthritis increasing the incidence of Listeria infections?The Journal of infection · 2010Review
- Mutations in MMP9 and MMP13 determine the mode of inheritance and the clinical spectrum of metaphyseal anadysplasia.American journal of human genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The metalloprotease (Mpl) of Listeria monocytogenes is a thermolysin-like protease that mediates the maturation of a broad-range phospholipase C, whose function contributes to the ability of this food-borne bacterial pathogen to survive intracellularly. Mpl is made as a proprotein that undergoes maturation by proteolytic cleavage of a large N-terminal prodomain. In this study, we identified the N terminus of mature Mpl and generated Mpl catalytic mutants to investigate the mechanism of Mpl maturation. We observed that Mpl activity was a prerequisite for maturation, suggesting a mechanism of autocatalysis. Furthermore, using a strain of L. monocytogenes expressing both the wild-type form and a catalytic mutant form of Mpl simultaneously, we determined that in vivo maturation of Mpl occurs exclusively by an intramolecular autocatalysis mechanism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.