Evidence map›Paper›PMID 17965164›Full record

ArticleJournal of bacteriology2008

Substitutions at auxiliary operator O3 enhance repression by nitrate-responsive regulator NarL at synthetic lac control regions in Escherichia coli K-12.

Valley Stewart, Peggy J Bledsoe

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Valley StewartSection of Microbiology, University of California, One Shields Avenue, Davis CA 95616-8665, USA. vjstewart@ucdavis.edu
Peggy J Bledsoe
University of California, Davis · US

Funding

GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLIR01GM036877 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI STEWART, VALLEY J. · 1986 to 2010
$2.4M
NIGMS NIH HHS GM36877NIGMS NIH HHS R01 GM036877
6 · The paper itself

Abstract

We constructed monocopy lac operon control regions in which the operators O1-lac and O3-lac were replaced by NarL and NarP binding sites from the nirB or napF operon control regions. The results support the hypothesis that DNA-bound dimers of phospho-NarL can participate in higher-order cooperative interactions.

Indexed as

Gene Expression Regulation, BacterialBase Sequencebeta-GalactosidaseBinding SitesCrosses, GeneticDimerizationDNA-Binding ProteinsEscherichia coli K12Escherichia coli ProteinsKineticsLac OperonMolecular Sequence DataMutagenesis, InsertionalPhosphorylationbeta-GalactosidaseDNA-Binding ProteinsEscherichia coli ProteinsNarL protein, E coli

Identifiers

PMID17965164
PMCPMC2223736
OpenAlexW2124578917

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.