ArticleJournal of bacteriology2008
Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Promoter contacts by TFB and TFEα during archaeal transcription initiation.Transcription · 2026Article
- The Thermococcales as a model system: historical perspectives and emerging tools.Journal of bacteriology · 2025Review
- The transcriptional regulator EarA and intergenic terminator sequences modulate archaellation inFrontiers in microbiology · 2023Article
- Direct binding of TFEα opens DNA binding cleft of RNA polymerase.Nature communications · 2020Article
- A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea.Nucleic acids research · 2018Article
- Same same but different: The evolution of TBP in archaea and their eukaryotic offspring.Transcription · 2017Article
- A global analysis of transcription reveals two modes of Spt4/5 recruitment to archaeal RNA polymerase.Nature microbiology · 2017Article
- Transcription Regulation in Archaea.Journal of bacteriology · 2016Review
- Molecular Mechanisms of Transcription Initiation-Structure, Function, and Evolution of TFE/TFIIE-Like Factors and Open Complex Formation.Journal of molecular biology · 2016Review
- Analyses of in vivo interactions between transcription factors and the archaeal RNA polymerase.Methods (San Diego, Calif.) · 2015Article
- Different roles of two transcription factor B proteins in the hyperthermophilic archaeon Thermococcus kodakarensis.Extremophiles : life under extreme conditions · 2014Article
- Carbohydrate metabolism in Archaea: current insights into unusual enzymes and pathways and their regulation.Microbiology and molecular biology reviews : MMBR · 2014Review
- The Sulfolobus initiator element is an important contributor to promoter strength.Journal of bacteriology · 2013Article
- Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage.Nucleic acids research · 2012Article
- Niche adaptation by expansion and reprogramming of general transcription factors.Molecular systems biology · 2011Article
- Archaeal RNA polymerase and transcription regulation.Critical reviews in biochemistry and molecular biology · 2011Review
- Functional analysis of the three TATA binding protein homologs in Methanosarcina acetivorans.Journal of bacteriology · 2010Article
- The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening.The Journal of biological chemistry · 2010Article
- Archaeal RNA polymerase.Current opinion in structural biology · 2009Review
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The genome of the hyperthermophile archaeon Pyrococcus furiosus encodes two transcription factor B (TFB) paralogs, one of which (TFB1) was previously characterized in transcription initiation. The second TFB (TFB2) is unusual in that it lacks recognizable homology to the archaeal TFB/eukaryotic TFIIB B-finger motif. TFB2 functions poorly in promoter-dependent transcription initiation, but photochemical cross-linking experiments indicated that the orientation and occupancy of transcription complexes formed with TFB2 at the strong gdh promoter are similar to the orientation and occupancy of transcription complexes formed with TFB1. Initiation complexes formed by TFB2 display a promoter opening defect that can be bypassed with a preformed transcription bubble, suggesting a mechanism to explain the low TFB2 transcription activity. Domain swaps between TFB1 and TFB2 showed that the low activity of TFB2 is determined mainly by its N terminus. The low activity of TFB2 in promoter opening and transcription can be partially relieved by transcription factor E (TFE). The results indicate that the TFB N-terminal region, containing conserved Zn ribbon and B-finger motifs, is important in promoter opening and that TFE can compensate for defects in the N terminus through enhancement of promoter opening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.