ArticleJournal of bacteriology2008
Interactions of the energy transducer TonB with noncognate energy-harvesting complexes.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- deepBreaks identifies and prioritizes genotype-phenotype associations using machine learning.Scientific reports · 2025Article
- The Intrinsically Disordered Region of ExbD Is Required for Signal Transduction.Journal of bacteriology · 2020Article
- Desert Dust as a Source of Iron to the Globally Important DiazotrophFrontiers in microbiology · 2017Article
- From Homodimer to Heterodimer and Back: Elucidating the TonB Energy Transduction Cycle.Journal of bacteriology · 2015Article
- New insights into iron acquisition by cyanobacteria: an essential role for ExbB-ExbD complex in inorganic iron uptake.The ISME journal · 2015Article
- The role of ExbD in periplasmic pH homeostasis in Helicobacter pylori.Helicobacter · 2013Article
- Functional features of TonB energy transduction systems of Acinetobacter baumannii.Infection and immunity · 2013Article
- Overexpression of the Escherichia coli TolQ protein leads to a null-FtsN-like division phenotype.MicrobiologyOpen · 2013Article
- Mutations in Escherichia coli ExbB transmembrane domains identify scaffolding and signal transduction functions and exclude participation in a proton pathway.Journal of bacteriology · 2013Article
- Article
- ExbD mutants define initial stages in TonB energization.Journal of molecular biology · 2012Article
- The same periplasmic ExbD residues mediate in vivo interactions between ExbD homodimers and ExbD-TonB heterodimers.Journal of bacteriology · 2011Article
- Mutations in the ExbB cytoplasmic carboxy terminus prevent energy-dependent interaction between the TonB and ExbD periplasmic domains.Journal of bacteriology · 2011Article
- Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore.Journal of bacteriology · 2011Article
- Energized outer membrane and spatial separation of metabolic processes in the hyperthermophilic Archaeon Ignicoccus hospitalis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cytoplasmic membrane protonmotive force energizes periplasmic interactions between ExbD and TonB.Molecular microbiology · 2009Article
- Molecular and genetic characterization of the TonB2-cluster TtpC protein in pathogenic vibrios.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The TonB and TolA proteins are energy transducers that couple the ion electrochemical potential of the cytoplasmic membrane to support energy-dependent processes at the outer membrane of the gram-negative envelope. The transfer of energy to these transducers is facilitated by energy-harvesting complexes, which are heteromultimers of cytoplasmic membrane proteins with homologies to proton pump proteins of the flagellar motor. Although the cognate energy-harvesting complex best services each transducer, components of the complexes (for TonB, ExbB and ExbD; for TolA, TolQ and TolR) are sufficiently similar that each complex can imperfectly replace the other. Previous investigations of this molecular cross talk considered energy-harvesting complex components expressed from multicopy plasmids in strains in which the corresponding genes were interrupted by insertions, partially absent due to polarity, or missing due to a larger deletion. These questions were reexamined here using strains in which individual genes were removed by precise deletions and, where possible, components were expressed from single-copy genes with native promoters. By more closely approximating natural stoichiometries between components, this study provided insight into the roles of energy-harvesting complexes in both the energization and the stabilization of TonB. Further, the data suggest a distinct role for ExbD in the TonB energy transduction cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.