ArticleJournal of bacteriology2008
Involvement of sensor kinases in the stress tolerance response of Streptococcus mutans.
Article in Journal of bacteriology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
64 citing papers in PubMed, 106 citations in OpenAlex.
- Molecular Regulation of Virulence and Dental Biofilm Formation in Streptococcus mutans: Unravelling the Crosstalk Between the VicRK and LiaSR Two-Component Systems.Molecular oral microbiology · 2026Review
- A novel insight into ComE-mediated activation of gene expression inMicrobiology spectrum · 2025Article
- Impacts of a DUF2207 Family Protein onMicroorganisms · 2023Article
- Redox Sensing Modulates the Activity of the ComE Response Regulator of Streptococcus mutans.Journal of bacteriology · 2021Article
- Cloning and Functional Characterization of PutativeJournal of microbiology and biotechnology · 2020Article
- Article
- Ribosomal protein L4 of Lactobacillus rhamnosus LRB alters resistance to macrolides and other antibiotics.Molecular oral microbiology · 2020Article
- Characterization of a stress tolerance-defective mutant of Lactobacillus rhamnosus LRB.Molecular oral microbiology · 2019Article
- CovR and VicRKX Regulate Transcription of the Collagen Binding Protein Cnm of Streptococcus mutans.Journal of bacteriology · 2018Article
- Role of CovR phosphorylation in gene transcription in Streptococcus mutans.Microbiology (Reading, England) · 2018Article
- Plasticity of the Pyruvate Node Modulates Hydrogen Peroxide Production and Acid Tolerance in Multiple Oral Streptococci.Applied and environmental microbiology · 2018Article
- ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36.Scientific reports · 2017Article
- AtlA Mediates Extracellular DNA Release, Which Contributes to Streptococcus mutans Biofilm Formation in an Experimental Rat Model of Infective Endocarditis.Infection and immunity · 2017Article
- Pleiotropic Regulation of Virulence Genes in Streptococcus mutans by the Conserved Small Protein SprV.Journal of bacteriology · 2017Article
- RNA-Seq Reveals Enhanced Sugar Metabolism inFrontiers in microbiology · 2017Article
- [Development of transcriptional regulators of Streptococcus mutans in cariogenic virulence].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Review
- CovR Regulates Streptococcus mutans Susceptibility To Complement Immunity and Survival in Blood.Infection and immunity · 2016Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Stress responses in Streptococcus species and their effects on the host.Journal of microbiology (Seoul, Korea) · 2015Review
- Deficiency of PdxR in Streptococcus mutans affects vitamin B6 metabolism, acid tolerance response and biofilm formation.Molecular oral microbiology · 2015Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The gram-positive bacterium Streptococcus mutans is the primary causative agent in the formation of dental caries in humans. The ability of S. mutans to adapt and to thrive in the hostile environment of the oral cavity suggests that this cariogenic pathogen is capable of sensing and responding to different environmental stimuli. This prompted us to investigate the role of two-component signal transduction systems (TCS), particularly the sensor kinases, in response to environmental stresses. Analysis of the annotated genome sequence of S. mutans indicates the presence of 13 putative TCS. Further bioinformatics analysis in our laboratory has identified an additional TCS in the genome of S. mutans. We verified the presence of the 14 sensor kinases by using PCR and Southern hybridization in 13 different S. mutans strains and found that not all of the sensor kinases are encoded by each strain. To determine the potential role of each TCS in the stress tolerance of S. mutans UA159, insertion mutations were introduced into the genes encoding the individual sensor kinases. We were successful in inactivating all of the sensor kinases, indicating that none of the TCS are essential for the viability of S. mutans. The mutant S. mutans strains were assessed for their ability to withstand various stresses, including osmotic, thermal, oxidative, and antibiotic stress, as well as the capacity to produce mutacin. We identified three sensor kinases, Smu486, Smu1128, and Smu1516, which play significant roles in stress tolerance of S. mutans strain UA159.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.