ArticleBiophysical journal2008
Rectification properties and pH-dependent selectivity of meningococcal class 1 porin.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Ion transport in biological ion channels beyond classical electrostatics. Nanoscale confinement, non-linear concentration patterns and interfacial effects.Biophysical reviews · 2026Review
- On the different sources of cooperativity in pH titrating sites of a membrane protein channel.The European physical journal. E, Soft matter · 2016Article
- Analysis of SARS-CoV E protein ion channel activity by tuning the protein and lipid charge.Biochimica et biophysica acta · 2013Article
- Diffusion, exclusion, and specific binding in a large channel: a study of OmpF selectivity inversion.Biophysical journal · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied the current rectification properties and selectivity of class 1 porin (PorA) from Neisseria meningitidis (strain H44/76 Delta 3 Delta 4) reconstituted in planar lipid membranes varying salt concentrations and pH. PorA channel shows voltage gating with a characteristic time remarkably longer than other porins. Its current-voltage asymmetry, evaluated as the current rectification ratio, changes nonmonotonically with salt concentration. Interestingly, it reaches its maximum value at physiological concentration. Porin selectivity, quantified by reversal potential measurements, is also significantly asymmetric. Depending on the direction of the salt gradient, the channel becomes more or less selective (10:1 vs. 5:1 Na(+)/Cl(-)). Besides, the reversal potential measurements suggest that porin inserts directionally following the concentration gradient. Measurements over a wide range of pH show that although PorA is strongly cation selective at pH >6, its selectivity gradually changes to anionic in an acidic medium (pH < 4). We show that a continuum electrodiffusion model quantitatively accounts for conductance and reversal potential measurements at positive and negative applied voltages.
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