ArticleBiophysical journal2008
Equilibrium dynamics of spermine-induced plasmid DNA condensation revealed by fluorescence lifetime correlation spectroscopy.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 34 citations in OpenAlex.
- An analysis of interactions between three structurally diverse anthocyanidins, as well as their glucosides, and model biological membranes, albumin, and plasmid DNA.Scientific reports · 2023Article
- Fluorescence Lifetime Correlation Spectroscopy (FLCS): concepts, applications and outlook.International journal of molecular sciences · 2012Review
- How environmental solution conditions determine the compaction velocity of single DNA molecules.Nucleic acids research · 2012Article
- DNA Binding Hydroxyl Radical Probes.Radiation physics and chemistry (Oxford, England : 1993) · 2012Article
- Early amyloidogenic oligomerization studied through fluorescence lifetime correlation spectroscopy.International journal of molecular sciences · 2012Article
- Recent developments in fluorescence correlation spectroscopy for diffusion measurements in planar lipid membranes.International journal of molecular sciences · 2010Review
- FRET fluctuation spectroscopy of diffusing biopolymers: contributions of conformational dynamics and translational diffusion.The journal of physical chemistry. B · 2010Article
- On the resolution capabilities and limits of fluorescence lifetime correlation spectroscopy (FLCS) measurements.Journal of fluorescence · 2010Article
- On mechanism of intermediate-sized circular DNA compaction mediated by spermine: contribution of fluorescence lifetime correlation spectroscopy.Journal of fluorescenceArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The spermine-induced DNA condensation is a first-order phase transition. Here, we apply a novel technique fluorescence lifetime correlation spectroscopy to analyze this transition in a greater detail. We show that the method allows for the observation of the condensed and uncondensed molecules simultaneously based solely on different fluorescence lifetimes of the intercalating fluorophore PicoGreen in the folded und unfolded domains of DNA. The auto- and cross-correlation functions reveal that a small fraction of the DNA molecules is involved in the dynamic intramolecular equilibrium. Careful inspection of the cross-correlation curves suggests that folding occurs gradually within milliseconds.
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Registered trials
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