ArticleNucleic acids research2008
MSY Breakpoint Mapper, a database of sequence-tagged sites useful in defining naturally occurring deletions in the human Y chromosome.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2013.Andrology · 2014Guideline
- Study on the influence of the sY1192 gene locus in the AZFb/c region on sperm quality and pregnancy outcome.Asian journal of andrology · 2025Article
- Article
- Partial-AZFc deletions in Chilean men with primary spermatogenic impairment: gene dosage and Y-chromosome haplogroups.Journal of assisted reproduction and genetics · 2020Article
- Case of Inherited Partial AZFa Deletion without Impact on Male Fertility.Case reports in genetics · 2019Article
- Cost-effective high-throughput single-haplotype iterative mapping and sequencing for complex genomic structures.Nature protocols · 2018Article
- Y chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia.International journal of reproductive biomedicine · 2017Article
- TMSB4Y is a candidate tumor suppressor on the Y chromosome and is deleted in male breast cancer.Oncotarget · 2015Article
- Prevalence of Y Chromosome Microdeletions in Idiopathic Azoospermia Cases in Central Indian Men.Journal of clinical and diagnostic research : JCDR · 2015Article
- Y chromosome azoospermia factor region microdeletions and transmission characteristics in azoospermic and severe oligozoospermic patients.International journal of clinical and experimental medicine · 2015Review
- Y choromosomal microdeletion screening in the workup of male infertility and its current status in India.International journal of fertility & sterility · 2014Review
- Intrachromosomal homologous recombination between inverted amplicons on opposing Y-chromosome arms.Genomics · 2013Article
- Fate of the human Y chromosome linked genes and loci in prostate cancer cell lines DU145 and LNCaP.BMC genomics · 2013Article
- Article
- Sex-specific genetic architecture of human disease.Nature reviews. Genetics · 2008Review
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4 authors.
Funding
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Abstract
Y chromosome deletions arise frequently in human populations, where they cause sex reversal and Turner syndrome and predispose individuals to infertility and germ cell cancer. Knowledge of the nucleotide sequence of the male-specific region of the Y chromosome (MSY) makes it possible to precisely demarcate such deletions and the repertoires of genes lost, offering insights into mechanisms of deletion and the molecular etiologies of associated phenotypes. Such deletion mapping is usually conducted using polymerase chain reaction (PCR) assays for the presence or absence of a series of Y-chromosomal DNA markers, or sequence-tagged sites (STSs). In the course of mapping intact and aberrant Y chromosomes during the past two decades, we and our colleagues have developed robust PCR assays for 1287 Y-specific STSs. These PCR assays amplify 1698 loci at an average spacing of <14 kb across the MSY euchromatin. To facilitate mapping of deletions, we have compiled a database of these STSs, MSY Breakpoint Mapper (http://breakpointmapper.wi.mit.edu/). When queried, this online database provides regionally targeted catalogs of STSs and nearby genes. MSY Breakpoint Mapper is useful for efficiently and systematically defining the breakpoint(s) of virtually any naturally occurring Y chromosome deletion.
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