ReviewGut2008
Functional GI disorders: from animal models to drug development.
Review in Gut, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01304355 (Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kynurenine Pathway Metabolites as Novel Translational Biological Markers of Irritable Bowel Syndrome: Relationship to Gastrointestinal Function, Cognition and Co-morbid Depression
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 160 citations in OpenAlex.
- Pooled it
- A cognitive-behavioral treatment for irritable bowel syndrome using interoceptive exposure to visceral sensations.Behaviour research and therapy · 2011Trial
- Effects of the N-methyl-D-aspartate receptor on temporal summation of second pain (wind-up) in irritable bowel syndrome.The journal of pain · 2011Trial
- Protocol for a randomized controlled study of Iyengar yoga for youth with irritable bowel syndrome.Trials · 2011Trial
- Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2010Trial
- Pathophysiological and Therapeutic Association between Brain-Gut Axis and Irritable Bowel Syndrome: A Systematic Review.Pakistan journal of medical sciences · 2026Review
- Similar Symptoms, Distinct Syndromes: Multi-modal Approach to the Patient with an IBD-IBS Overlap.Digestive diseases and sciences · 2026Review
- Therapeutic potential ofMicrobiome research reports · 2026Article
- Interactions between CNS regulation and serotonergic modulation of crayfish hindgut motility.Royal Society open science · 2025Article
- How Discrimination Gets Under the Skin: Biological Determinants of Discrimination Associated With Dysregulation of the Brain-Gut Microbiome System and Psychological Symptoms.Biological psychiatry · 2023Article
- Gut Microbiome-Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders.ACS chemical neuroscience · 2023Review
- Regional brain activation during rectal distention and attenuation with alosetron in a nonhuman primate model of irritable bowel syndrome.FASEB bioAdvances · 2022Article
- Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases.International journal of biological sciences · 2022Review
- Review of Abdominal Migraine in Children.Gastroenterology & hepatology · 2020Article
- Brain-gut-microbiome interactions in obesity and food addiction.Nature reviews. Gastroenterology & hepatology · 2020Review
- Yoga as a Therapy for Irritable Bowel Syndrome.Digestive diseases and sciences · 2020Review
- The Role of Chronic Stress in Normal Visceroception: Insights From an Experimental Visceral Pain Study in Healthy Volunteers.Frontiers in psychiatry · 2020Article
- Gastroparesis and Functional Dyspepsia: A Blurring Distinction of Pathophysiology and Treatment.Journal of neurogastroenterology and motility · 2019Review
- Brain-Gut Axis: Clinical Implications.Gastroenterology clinics of North America · 2018Review
- Identification of Individuals with Functional Dyspepsia With a Simple, Minimally Invasive Test: A Single Center Cohort Study of the Oral Capsaicin Test.The American journal of gastroenterology · 2018Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Despite considerable efforts by academic researchers and by the pharmaceutical industry, the development of novel pharmacological treatments for irritable bowel syndrome (IBS) and other functional gastrointestinal (GI) disorders has been slow and disappointing. The traditional approach to identifying and evaluating novel drugs for these symptom-based syndromes has relied on a fairly standard algorithm using animal models, experimental medicine models and clinical trials. In the current article, the empirical basis for this process is reviewed, focusing on the utility of the assessment of visceral hypersensitivity and GI transit, in both animals and humans, as well as the predictive validity of preclinical and clinical models of IBS for identifying successful treatments for IBS symptoms and IBS-related quality of life impairment. A review of published evidence suggests that abdominal pain, defecation-related symptoms (urgency, straining) and psychological factors all contribute to overall symptom severity and to health-related quality of life. Correlations between readouts obtained in preclinical and clinical models and respective symptoms are small, and the ability to predict drug effectiveness for specific as well as for global IBS symptoms is limited. One possible drug development algorithm is proposed which focuses on pharmacological imaging approaches in both preclinical and clinical models, with decreased emphasis on evaluating compounds in symptom-related animal models, and more rapid screening of promising candidate compounds in man.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.