ArticleVirology2008
NS3 protein of hepatitis C virus regulates cyclooxygenase-2 expression through multiple signaling pathways.
Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- From viruses to cancer: exploring the role of the hepatitis C virus NS3 protein in carcinogenesis.Infectious agents and cancer · 2024Review
- In Memory of the Virologist Jianguo Wu, 1957-2022.Viruses · 2023Article
- Prostaglandin E2 and Receptors: Insight Into Tumorigenesis, Tumor Progression, and Treatment of Hepatocellular Carcinoma.Frontiers in cell and developmental biology · 2022Review
- A review of antioxidant and pharmacological properties of phenolic compounds inJournal of traditional and complementary medicine · 2018Review
- Lobohedleolide suppresses hepatitis C virus replication via JNK/c-Jun-C/EBP-mediated down-regulation of cyclooxygenase-2 expression.Scientific reports · 2018Article
- Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects.PloS one · 2018Article
- Anti-infective potential of catechins and their derivatives against viral hepatitis.Clinical and experimental vaccine research · 2018Review
- The protection of meloxicam against chronic aluminium overload-induced liver injury in rats.Oncotarget · 2017Article
- Roles of p53 in extrinsic factor-induced liver carcinogenesis.Hepatoma research · 2017Article
- Article
- Betulinic acid exerts anti-hepatitis C virus activity via the suppression of NF-κB- and MAPK-ERK1/2-mediated COX-2 expression.British journal of pharmacology · 2015Article
- HCV NS5A Up-Regulates COX-2 Expression via IL-8-Mediated Activation of the ERK/JNK MAPK Pathway.PloS one · 2015Article
- Hepatitis C virus-mediated angiogenesis: molecular mechanisms and therapeutic strategies.World journal of gastroenterology · 2014Review
- Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2013Review
- HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1.PLoS pathogens · 2013Article
- Hepatitis C virus activates Bcl-2 and MMP-2 expression through multiple cellular signaling pathways.Journal of virology · 2012Article
- Classical swine fever virus NS5A protein localizes to endoplasmic reticulum and induces oxidative stress in vascular endothelial cells.Virus genes · 2012Article
- Hepatitis C virus activates interleukin-1β via caspase-1-inflammasome complex.The Journal of general virology · 2012Article
- San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression.Journal of viral hepatitis · 2011Article
- Induction of cyclooxygenase-2 expression by hepatitis B virus depends on demethylation-associated recruitment of transcription factors to the promoter.Virology journal · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) causes chronic hepatitis, which often results in the development of liver cirrhosis and hepatocellular carcinoma (HCC) worldwide. In this study, we demonstrated that the non-structural protein NS3 of HCV enhances cyclooxygenase-2 (COX-2) gene promoter activity, COX-2 mRNA expression, COX-2 protein production, and prostaglandin E2 (PGE2) release in HepG2 cells in a concentration-dependent fashion. We also showed that transcription factor NF-kappaB is required for the activation of COX-2 regulated by NS3. In addition, multiple signaling pathways are involved cooperatively in the expression of COX-2 activated by the viral protein in a calcium-independent manner, which requires signaling components including JNK, ERK, and PKD2. A thorough investigation of mechanism involved in the activation of COX-2 regulated by HCV would provide insights into our understanding the processes of liver inflammatory response and hepatocellular carcinoma development caused by the viral infection and also into the development of novel therapeutics against HCV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.