ArticleJournal of autoimmune diseases2007
Islet cell autoantibodies in African patients with Type 1 and Type 2 diabetes in Dar es Salaam Tanzania: a cross sectional study.
Article in Journal of autoimmune diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Global and regional estimates of the morbidity due to type I diabetes among children aged 0-4 years: a systematic review and analysis.Journal of global health · 2018Pooled it
- Islet autoantibodies as predictors of type 1 diabetes development, a systematic review with public health implications for Africa.Diabetology & metabolic syndrome · 2026Review
- Diabetes, Celiac, and Thyroid-Related Autoantibodies in HLA Genotyped Ethiopian Children and Adolescents With Type 1 Diabetes: A Cross-Sectional Study.Pediatric diabetes · 2025Article
- Type 1 diabetes, celiac disease, and autoimmune thyroiditis autoantibodies in population-based type 2 diabetes patients.Journal of clinical & translational endocrinology · 2024Article
- The phenotype of type 1 diabetes in sub-Saharan Africa.Frontiers in public health · 2023Review
- The relationship between GAD65 autoantibody and the risk of T1DM onset.Journal of diabetes and metabolic disorders · 2022Review
- Prevalence and factors associated with latent autoimmune diabetes in adults (LADA): a cross-sectional study.BMC endocrine disorders · 2022Article
- Islet autoantibody positivity in an adult population with recently diagnosed diabetes in Uganda.PloS one · 2022Article
- Severe acute respiratory syndrome coronavirus 2 as a potential cause of type 1 diabetes facilitated by spike protein receptor binding domain attachment to human islet cells: An illustrative case study and experimental data.Diabetic medicine : a journal of the British Diabetic Association · 2021Article
- Latent Autoimmune Diabetes in Adults (LADA) and its Metabolic Characteristics among Yemeni Type 2 Diabetes Mellitus Patients.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Type 1 diabetes in Africa: an immunogenetic study in the Amhara of North-West Ethiopia.Diabetologia · 2020Article
- Geographic location determines beta-cell autoimmunity among adult Ghanaians: Findings from the RODAM study.Immunity, inflammation and disease · 2020Article
- Genetics of Monogenic Diabetes: Present Clinical Challenges.Current diabetes reports · 2018Review
- Type 1 Diabetes in a Resource-Poor Setting: Malnutrition Related, Malnutrition Modified, or Just Diabetes?Current diabetes reports · 2018Review
- Genetics of type 1 diabetes.Pediatric diabetes · 2018Review
- Thyroid autoimmunity and function among Ugandan children and adolescents with type-1 diabetes mellitus.The Pan African medical journal · 2014Article
- Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: relation to autoantibody status and comparison with Belgian patients.Diabetes research and clinical practice · 2014Article
- Comparison of autoantibody-positive and autoantibody-negative pediatric participants enrolled in the T1D Exchange clinic registry.Journal of diabetes · 2013Article
- Latent Autoimmune Diabetes Mellitus in Adults (LADA) and it's characteristics in a subset of Nigerians initially managed for type 2 diabetes.International archives of medicine · 2012Article
- Insulin-requiring diabetes in Ethiopia: associations with poverty, early undernutrition and anthropometric disproportion.European journal of clinical nutrition · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of the present study was to assess the occurrence of glutamic acid decarboxylase autoantibodies (GADA) and insulinoma antigen 2 autoantibodies (IA2A) among patients of African origin in Dar es Salaam, Tanzania and to compare the occurrence of autoimmune mediated Type 1 diabetes with findings previously reported from the same place and from other African diabetic populations.
methodsTwo hundred and forty five patients from the diabetic clinic at Muhimbili Hospital were recruited for a cross sectional study. Patients were clinically classified into groups with Type 1 (T1D) and Type 2 diabetes (T2D); there were 94 patients with T1D and 151 with T2D. Autoantibodies for GAD and IA2 were measured with an assay based on radioligand binding. Fasting and random blood glucose, HbA1c, and C-peptide levels were also determined.
resultsOf the patients with T1D, 28 (29.8%) were GADA positive and 20 (21.3%) were IA2A positive. The overall occurrence of any autoantibody was 42.6%. The GAD and IA2 autoantibodies were detected more frequently among patients with T1D than among patients with T2D (P < 0.001). A higher autoantibody prevalence was observed with combined GADA and IA2A measurements compared to individual autoantibody measurements; 40 (42.6%) patients with T1D versus 11 (7.3%) with T2D had at least one positive autoantibody titer. There was no correlation between duration of disease and detection of autoantibodies in patients with T1D. There was a strong association with family history of diabetes among the autoantibody positive versus autoantibody negative patients with T1D (p < 0.01).
conclusionThe prevalence of GAD and IA2 autoantibodies among African patients with T1D in Dar es Salaam was the same as that reported previously for South Africa and Ethiopia. It was much higher than the prevalence of islet cell autoantibodies (ICA) reported from the same clinic about 15 years ago. For unknown reasons the prevalence of pancreatic related autoantibodies in this African population is lower than the prevalence found among Caucasian populations.
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