ArticleWorld journal of gastroenterology2007
CYP2E1 Rsa I polymorphism impacts on risk of colorectal cancer association with smoking and alcohol drinking.
Article in World journal of gastroenterology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Associations of CYP2E1 rs2031920 and rs3813867 polymorphisms with colorectal cancer risk: a systemic review and meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Association between alcohol consumption and cancers in the Chinese population--a systematic review and meta-analysis.PloS one · 2011Pooled it
- CYP2E1 PstI/RsaI polymorphism and colorectal cancer risk: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- CYP2D6, CYP2E1 Gene Polymorphisms and Gastrointestinal Cancer Risk in Rural Maharashtra: A Hospital Based Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Cytochrome P2E1 (CYP2E1) Gene Polymorphism as a Potential Prognostic Biomarker in Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Effects of interactions between common genetic variants and alcohol consumption on colorectal cancer risk.Oncotarget · 2018Article
- Effects of gene polymorphisms of metabolic enzymes on the association between red and processed meat consumption and the development of colon cancer; a literature review.Journal of nutritional science · 2018Review
- Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters.Disease markers · 2018Article
- Polymorphisms of the CYP1A1 and CYP2E1 genes in head and neck squamous cell carcinoma risk.Molecular biology reports · 2012Article
- Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population.Human genomics · 2011Article
- Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population.World journal of gastroenterology · 2008Article
- Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate associations between the Rsa I polymorphism of CYP2E1 and risk of colorectal cancer.
methodsA case-control study was conducted with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. Genomic DNA samples were assayed for restriction fragment length polymorphisms in CYP2E1 by PCR amplification followed by digestion with Rsa I. Information on smoking and alcohol drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model.
resultsThe proportional distribution of the CYP2E1 Rsa I c1/c1, c1/c2 and c2/c2 genotypes were 61.4%, 35.6% and 3.0% in controls, 60.6%, 33.7% and 5.8% in colon cancer cases, and 58.4%, 34.0% and 7.7% in rectal cancer cases, respectively. A significant difference was noted between controls and rectal cancer cases (P = 0.029), the c2/c2 genotype being associated with elevated OR (adjusted age, sex and status of the smoking and alcohol drinking) for rectal cancer (1.64, 95% CI, 1.12-2.41, vs c1 allele carriers), but not for colon cancer. In interaction analysis between the CYP2E1 Rsa I genotype and smoking and drinking habits, we found a significant cooperative action between the c2/c2 genotype and alcohol drinking in the sex-, age-adjusted ORs for both colon (4.74, 95% CI, 1.10-20.40) and rectal (5.75, 95% CI, 1.65-20.05) cancers. Among non-smokers, the CYP2E1 Rsa I c2/c2 genotype was also associated with elevated ORs in the two sites (1.95, 95% CI, 0.99-3.86 and 2.30, 95% CI, 1.32-3.99).
conclusionThe results of the present study suggest that the CYP2E1 c2/c2 genotype increases susceptibility to rectal cancer and the gene-environmental interactions between the CYP2E1 polymorphism and smoking or alcohol drinking exist for colorectal neoplasia in general.
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