ReviewNeurochemical research2008
11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function.
Review in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Systematic metabolomic studies identified adult adiposity biomarkers with acetylglycine associated with fat lossFrontiers in molecular biosciences · 2023Article
- 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) mediates insulin resistance through JNK activation in adipocytes.Scientific reports · 2016Article
- Elevated hepatic 11β-hydroxysteroid dehydrogenase type 1 induces insulin resistance in uremia.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Aged rats are hypo-responsive to acute restraint: implications for psychosocial stress in aging.Frontiers in aging neuroscience · 2014Article
- Dexamethasone-induced selenoprotein S degradation is required for adipogenesis.Journal of lipid research · 2013Article
- Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation.Current atherosclerosis reports · 2013Review
- Mast cells express 11β-hydroxysteroid dehydrogenase type 1: a role in restraining mast cell degranulation.PloS one · 2013Article
- Article
- 11beta-hydroxysteroid dehydrogenase type 1 expression is increased in the aged mouse hippocampus and parietal cortex and causes memory impairments.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Glucocorticoid dysregulations and their clinical correlates. From receptors to therapeutics.Annals of the New York Academy of Sciences · 2009Review
- Glucocorticoid receptor haploinsufficiency causes hypertension and attenuates hypothalamic-pituitary-adrenal axis and blood pressure adaptions to high-fat diet.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Reduction of hepatic glucocorticoid receptor and hexose-6-phosphate dehydrogenase expression ameliorates diet-induced obesity and insulin resistance in mice.Journal of molecular endocrinology · 2008Article
- HPA axis responsiveness to stress: implications for healthy aging.Experimental gerontologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is an intracellular amplifier of glucocorticoid action. By converting intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone) into their active forms (cortisol, corticosterone), 11beta-HSD1 increases glucocorticoid access to receptors. Glucocorticoid hormones modulate diverse physiological processes, linking circadian rhythms to food seeking, motivational and cognitive behaviours, as well as intermediary metabolism and immune responses. They are a key component of pathways that buffer the organism against stressful challenges. Here we review the part played in these processes by 11beta-HSD1, and discuss the promise of inhibitors of 11beta-HSD1 in alleviating disorders associated with cumulative stress.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.