ArticleThe EMBO journal2008
ACF catalyses chromatosome movements in chromatin fibres.
Article in The EMBO journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
- Remodeling of Individual Nucleosomes in Nucleosome Arrays.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.Nature structural & molecular biology · 2022Article
- The emerging role of ISWI chromatin remodeling complexes in cancer.Journal of experimental & clinical cancer research : CR · 2021Review
- Article
- Cell-free genomics reveal intrinsic, cooperative and competitive determinants of chromatin interactions.Nucleic acids research · 2021Article
- A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling.Nucleic acids research · 2019Article
- Gene-Specific H1 Eviction through a Transcriptional Activator→p300→NAP1→H1 Pathway.Molecular cell · 2019Article
- Emerging roles of linker histones in regulating chromatin structure and function.Nature reviews. Molecular cell biology · 2018Review
- The ISW1 and CHD1 ATP-dependent chromatin remodelers compete to set nucleosome spacing in vivo.Nucleic acids research · 2016Article
- Computational study of remodeling in a nucleosomal array.The European physical journal. E, Soft matter · 2015Article
- A genetic screen and transcript profiling reveal a shared regulatory program for Drosophila linker histone H1 and chromatin remodeler CHD1.G3 (Bethesda, Md.) · 2015Article
- ISWI remodelling of physiological chromatin fibres acetylated at lysine 16 of histone H4.PloS one · 2014Article
- H1 histones: current perspectives and challenges.Nucleic acids research · 2013Review
- The ATPase domain of ISWI is an autonomous nucleosome remodeling machine.Nature structural & molecular biology · 2013Article
- The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosome.Nucleic acids research · 2012Article
- Base excision repair of 8-oxoG in dinucleosomes.Nucleic acids research · 2012Article
- Functional antagonism between Sas3 and Gcn5 acetyltransferases and ISWI chromatin remodelers.PLoS genetics · 2012Article
- Activation-induced disruption of nucleosome position clusters on the coding regions of Gcn4-dependent genes extends into neighbouring genes.Nucleic acids research · 2011Article
- Role for hACF1 in the G2/M damage checkpoint.Nucleic acids research · 2011Article
- ATP-dependent chromatin remodeling factors and their roles in affecting nucleosome fiber composition.International journal of molecular sciences · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Nucleosome-remodelling factors containing the ATPase ISWI, such as ACF, render DNA in chromatin accessible by promoting the sliding of histone octamers. Although the ATP-dependent repositioning of mononucleosomes is readily observable in vitro, it is unclear to which extent nucleosomes can be moved in physiological chromatin, where neighbouring nucleosomes, linker histones and the folding of the nucleosomal array restrict mobility. We assembled arrays consisting of 12 nucleosomes or 12 chromatosomes (nucleosomes plus linker histone) from defined components and subjected them to remodelling by ACF or the ATPase CHD1. Both factors increased the access to DNA in nucleosome arrays. ACF, but not CHD1, catalysed profound movements of nucleosomes throughout the array, suggesting different remodelling mechanisms. Linker histones inhibited remodelling by CHD1. Surprisingly, ACF catalysed significant repositioning of entire chromatosomes in chromatin containing saturating levels of linker histone H1. H1 inhibited the ATP-dependent generation of DNA accessibility by only about 50%. This first demonstration of catalysed chromatosome movements suggests that the bulk of interphase euchromatin may be rendered dynamic by dedicated nucleosome-remodelling factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.