Trial reportAmerican journal of respiratory and critical care medicine2008
The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations.
Trial report in American journal of respiratory and critical care medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- Lung volume reduction surgery for diffuse emphysema.The Cochrane database of systematic reviews · 2016Pooled it
- Several clinical interests regarding lung volume reduction surgery for severe emphysema: meta-analysis and systematic review of randomized controlled trials.Journal of cardiothoracic surgery · 2011Pooled it
- A multicenter pilot study of a bronchial valve for the treatment of severe emphysema.Respiration; international review of thoracic diseases · 2010Trial
- Endobronchial Valves for Bronchoscopic Lung Volume Reduction in Severe Emphysema: A Reversible and Non-Surgical Treatment for Patients Who May or May Not Be Candidates for Lung Transplantation.Diagnostics (Basel, Switzerland) · 2026Review
- Non-pharmacologic Prevention of Acute Exacerbation Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2025Article
- Surgical and Interventional Approaches in COPD.Respiratory care · 2023Review
- Journal Club - Endobronchial Valve Bronchoscopic Lung Volume Reduction.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2019Article
- Clinical burden of illness among patients with severe eosinophilic COPD.International journal of chronic obstructive pulmonary disease · 2019Article
- Patient Preferences for Endobronchial Valve Treatment of Severe Emphysema.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2018Article
- Lung volume reduction surgery or bronchoscopic lung volume reduction: is there an algorithm for allocation?Journal of thoracic disease · 2018Review
- Optimizing bronchodilation in the prevention of COPD exacerbations.Respiratory research · 2017Review
- Optimizing Treatment of Elderly COPD Patients: What Role for Inhaled Corticosteroids?Drugs & aging · 2015Review
- COPD: it is time to change!International journal of chronic obstructive pulmonary disease · 2015Article
- Preventing COPD exacerbations: new options for a crucial and growing problem.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2014Article
- Risk-to-benefit ratio of inhaled corticosteroids in patients with COPD.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Review
- No room to breathe: the importance of lung hyperinflation in COPD.Primary care respiratory journal : journal of the General Practice Airways Group · 2013Review
- The role of bronchodilator treatment in the prevention of exacerbations of COPD.The European respiratory journal · 2012Review
- A lifetime Markov model for the economic evaluation of chronic obstructive pulmonary disease.PharmacoEconomics · 2012Article
- Dyspnea review for the palliative care professional: treatment goals and therapeutic options.Journal of palliative medicine · 2012Review
- E pluribus plurima: multidimensional indices and clinical phenotypes in COPD.Respiratory research · 2011Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
Abstract
rationaleLung volume reduction surgery (LVRS) has been demonstrated to provide a functional and mortality benefit to a select group of subjects with chronic obstructive pulmonary disease (COPD). The effect of LVRS on COPD exacerbations has not been as extensively studied, and whether improvement in postoperative lung function alters the risk of disease exacerbations is not known.
objectivesTo examine the effect, and mechanism of potential benefit, of LVRS on COPD exacerbations by comparing the medical and surgical cohorts of the National Emphysema Treatment Trial (NETT).
methodsA COPD exacerbation was defined using Centers for Medicare and Medicaid Services data and International Classification of Diseases, Ninth Revision, discharge diagnosis. MEASUREMENTS AND MAIN
resultsThere was no difference in exacerbation rate or time to first exacerbation between the medical and surgical cohorts during the year before study randomization (P = 0.58 and 0.85, respectively). Postrandomization, the surgical cohort experienced an approximate 30% reduction in exacerbation frequency (P = 0.0005). This effect was greatest in those subjects with the largest postoperative improvement in FEV(1) (P = 0.04) when controlling for changes in other spirometric measures of lung function, lung capacities, and room air arterial blood gas tensions. Finally, LVRS increased the time to first exacerbation in both those subjects with and those without a prior history of exacerbations (P = 0.0002 and P < 0.0001, respectively).
conclusionsLVRS reduces the frequency of COPD exacerbations and increases the time to first exacerbation. One explanation for this benefit may be the postoperative improvement in lung function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.