ArticleProceedings of the National Academy of Sciences of the United States of America2007
Analysis of nematode mechanics by piezoresistive displacement clamp.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 160 citations in OpenAlex.
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- The influence of internal pressure and neuromuscular agents onFrontiers in bioengineering and biotechnology · 2024Article
- Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematodeAmerican journal of physiology. Cell physiology · 2023Review
- Body stiffness is a mechanical property that facilitates contact-mediated mate recognition in Caenorhabditis elegans.Current biology : CB · 2023Article
- Condensed tannins act as anthelmintics by increasing the rigidity of the nematode cuticle.Scientific reports · 2022Article
- Studying Stickiness: Methods, Trade-Offs, and Perspectives in Measuring Reversible Biological Adhesion and Friction.Biomimetics (Basel, Switzerland) · 2022Review
- Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant.Biophysical journal · 2022Article
- Reciprocal interactions between transforming growth factor beta signaling and collagens: Insights from Caenorhabditis elegans.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Characterization of larval growth inmicroPublication biology · 2022Article
- Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis.PLoS biology · 2020Article
- Nonlinear Elastic and Inelastic Properties of Cells.Journal of biomechanical engineering · 2020Review
- High-sensitivity and high-specificity biomechanical imaging by stimulated Brillouin scattering microscopy.Nature methods · 2020Article
- Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans.Nature communications · 2020Article
- Extending the Capabilities of Molecular Force Sensors via DNA Nanotechnology.Critical reviews in biomedical engineering · 2020Review
- Force microscopy of theMicrosystems & nanoengineering · 2020Article
- Article
- HowGenetics · 2019Review
- Signatures of proprioceptive control inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- The bodies ofmicroPublication biology · 2018Article
- The tactile receptive fields of freely moving Caenorhabditis elegans nematodes.Integrative biology : quantitative biosciences from nano to macro · 2018Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Studying animal mechanics is critical for understanding how signals in the neuromuscular system give rise to behavior and how force-sensing organs and sensory neurons work. Few techniques exist to provide forces and displacements appropriate for such studies. To address this technological gap, we developed a metrology using piezoresistive cantilevers as force-displacement sensors coupled to a feedback system to apply and maintain defined load profiles to micrometer-scale animals. We show that this system can deliver forces between 10(-8) and 10(-3) N across distances of up to 100 mum with a resolution of 12 nN between 0.1 Hz and 100 kHz. We use this new metrology to show that force-displacement curves of wild-type nematodes (Caenorhabditis elegans) are linear. Because nematodes have approximately cylindrical bodies, this finding demonstrates that nematode body mechanics can be modeled as a cylindrical shell under pressure. Little is known about the relative importance of hydrostatic pressure and shell mechanics, however. We show that dissipating pressure by cuticle puncture or decreasing it by hyperosmotic shock has only a modest effect on stiffness, whereas defects in the dpy-5 and lon-2 genes, which alter body shape and cuticle proteins, decrease and increase stiffness by 25% and 50%, respectively. This initial analysis of C. elegans body mechanics suggests that shell mechanics dominates stiffness and is a first step in understanding how body mechanics affect locomotion and force sensing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.