ArticleProceedings of the National Academy of Sciences of the United States of America2007
A protein key to plant virus transmission at the tip of the insect vector stylet.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 188 citations in OpenAlex.
- Aphid effector Mp10 balances immune suppression and defence activation through EDS1-dependent modulation of plant DAMP responses.The New phytologist · 2025Article
- Stylet cuticular gene-directed mutagenesis impairs the pea aphid vector capacity to transmit a plant virus.PLoS pathogens · 2025Article
- The first arriving virus shapes within-host viral diversity during natural epidemics.Proceedings. Biological sciences · 2023Article
- Transcriptomic and Proteomic Analyses ofBiology · 2023Article
- Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode.eLife · 2023Article
- The cauliflower mosaic virus transmission helper protein P2 modifies directly the probing behavior of the aphid vector Myzus persicae to facilitate transmission.PLoS pathogens · 2023Article
- Role of Acrostyle Cuticular Proteins in the Retention of an Aphid Salivary Effector.International journal of molecular sciences · 2022Article
- Identification of Endogenous Genes for Normalizing Titer Variation of Citrus Tristeza Virus in Aphids at Different Post-acquisition Feeding Times.The plant pathology journal · 2022Article
- A Review on Transcriptional Responses of Interactions between Insect Vectors and Plant Viruses.Cells · 2022Review
- Insight into aphid mediatedFrontiers in microbiology · 2022Review
- Sugarcane multitrophic interactions: Integrating belowground and aboveground organisms.Genetics and molecular biology · 2022Article
- A plant virus satellite RNA directly accelerates wing formation in its insect vector for spread.Nature communications · 2021Article
- Enhancing Capsid Proteins Capacity in Plant Virus-Vector Interactions and Virus Transmission.Cells · 2021Review
- A vector whitefly endocytic receptor facilitates the entry of begomoviruses into its midgut cells via binding to virion capsid proteins.PLoS pathogens · 2020Article
- Article
- Route of a Multipartite Nanovirus across the Body of Its Aphid Vector.Journal of virology · 2020Article
- Cuticular Structure Proteomics in the Pea AphidJournal of proteome research · 2020Article
- Insect Mouthpart Transcriptome Unveils Extension of Cuticular Protein Repertoire and Complex Organization.iScience · 2020Article
- Review
- Evolution and ecology of plant viruses.Nature reviews. Microbiology · 2019Review
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hundreds of species of plant viruses, many of them economically important, are transmitted by noncirculative vector transmission (acquisition by attachment of virions to vector mouthparts and inoculation by subsequent release), but virus receptors within the vector remain elusive. Here we report evidence for the existence, precise location, and chemical nature of the first receptor for a noncirculative virus, cauliflower mosaic virus, in its insect vector. Electron microscopy revealed virus-like particles in a previously undescribed anatomical zone at the extreme tip of the aphid maxillary stylets. A novel in vitro interaction assay characterized binding of cauliflower mosaic virus protein P2 (which mediates virus-vector interaction) to dissected aphid stylets. A P2-GFP fusion exclusively labeled a tiny cuticular domain located in the bottom-bed of the common food/salivary duct. No binding to stylets of a non-vector species was observed, and a point mutation abolishing P2 transmission activity correlated with impaired stylet binding. The novel receptor appears to be a nonglycosylated protein deeply embedded in the chitin matrix. Insight into such insect receptor molecules will begin to open the major black box of this scientific field and might lead to new strategies to combat viral spread.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.