ArticleThe Journal of physiology2007
GABAA-receptor modification in taurine transporter knockout mice causes striatal disinhibition.
Article in The Journal of physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Differential metabolic and cellular brain regional susceptibility in adult rats with chronic liver disease.Metabolic brain disease · 2026Article
- Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development.Metabolites · 2022Article
- Taurine depletion during fetal and postnatal development blunts firing responses of neocortical layer II/III pyramidal neurons.Frontiers in molecular neuroscience · 2022Article
- Age-related decline in the taurine content of the skin in rodents.Amino acids · 2021Article
- Effects and Mechanisms of Taurine as a Therapeutic Agent.Biomolecules & therapeutics · 2018Review
- L-DOPA Reverses the Increased Free Amino Acids Tissue Levels Induced by Dopamine Depletion and Rises GABA and Tyrosine in the Striatum.Neurotoxicity research · 2016Article
- Glycine transporter-1 controls nonsynaptic inhibitory actions of glycine receptors in the neonatal rat hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Intraspinal transplantation of motoneuron-like cell combined with delivery of polymer-based glial cell line-derived neurotrophic factor for repair of spinal cord contusion injury.Neural regeneration research · 2014Article
- Activity-dependent endogenous taurine release facilitates excitatory neurotransmission in the neocortical marginal zone of neonatal rats.Frontiers in cellular neuroscience · 2014Article
- Metabolic maturation of the human brain from birth through adolescence: insights from in vivo magnetic resonance spectroscopy.Cerebral cortex (New York, N.Y. : 1991) · 2013Article
- Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors.PloS one · 2013Article
- Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents.The Journal of biological chemistry · 2012Article
- Effects of valproic acid, a histone deacetylase inhibitor, on improvement of locomotor function in rat spinal cord injury based on epigenetic science.Iranian biomedical journal · 2012Article
- Release of endogenous amino acids from the striatum from developing and adult mice in ischemia.Neurochemical research · 2011Article
- Adult renal function is modified by perinatal taurine status in conscious male rats.Journal of biomedical science · 2010Article
- Taurine regulates insulin release from pancreatic beta cell lines.Journal of biomedical science · 2010Article
- Evaluating risks for vigabatrin treatment.Epilepsy currentsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Striatum is involved in the regulation of movements and motor skills. We have shown previously, that the osmolyte and neuromodulator taurine plays a role in striatal plasticity. We demonstrate now that hereditary taurine deficiency in taurine-transporter knock-out (TAUT KO) mice results in disinhibition of striatal network activity, which can be corrected by taurine supplementation. Modification of GABAA but not glycine receptors (taurine is a ligand for both receptor types) underlies this disinhibition. Whole-cell recordings from acutely isolated as well as cultured striatal neurons revealed a decreased agonist sensitivity of the GABAA receptor in TAUT KO neurons in the absence of changes in the maximal GABA-evoked current amplitude. The striatal GABA level in TAUT KO mice was unchanged. The amplitude enhancement of spontaneous IPSCs by zolpidem was stronger in TAUT KO than in wild-type (WT) animals. Tonic inhibition was absent in striatal neurons under control conditions but was detected after incubation with the GABA-transaminase inhibitor vigabatrin: bicuculline induced a larger shift of baseline current in WT as compared to TAUT KO neurons. Lack of taurine leads to reduced sensitivity of synaptic and extrasynaptic GABAA receptors and consequently to disinhibition. These findings help in understanding neuropathologies accompanied by the loss of endogenous taurine, for instance in hepatic encephalopathy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.