Evidence map›Paper›PMID 17962334›Full record

Trial reportThe Journal of physiology2008

Locomotor muscle fatigue modifies central motor drive in healthy humans and imposes a limitation to exercise performance.

Markus Amann, Jerome A Dempsey

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Task Failure in Endurance Sports: A Review.Sports medicine (Auckland, N.Z.) · 2026
    Review

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Markus AmannThe John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Medical School, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA. amann@wisc.edu
Jerome A Dempsey

Funding

HUMAN VENTILATORY ADAPTIONR01HL015469 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, JEROME A · 1985 to 2011
$3.7M
HUMAN VENTILLATORY ADAPTATIONR37HL015469 · NHLBI · UNIVERSITY OF WISCONSIN MADISON · PI DEMPSEY, JEROME A · 1988 to 1996
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NHLBI NIH HHS HL 15469NHLBI NIH HHS R01 HL015469
6 · The paper itself

Abstract

We asked whether the central effects of fatiguing locomotor muscle fatigue exert an inhibitory influence on central motor drive to regulate the total degree of peripheral fatigue development. Eight cyclists performed constant-workload prefatigue trials (a) to exhaustion (83% of peak power output (W(peak)), 10 +/- 1 min; PFT(83%)), and (b) for an identical duration but at 67% W(peak) (PFT(67%)). Exercise-induced peripheral quadriceps fatigue was assessed via changes in potentiated quadriceps twitch force (DeltaQ(tw,pot)) from pre- to post-exercise in response to supra-maximal femoral nerve stimulation (DeltaQ(tw,pot)). On different days, each subject randomly performed three 5 km time trials (TTs). First, subjects repeated PFT(83%) and the TT was started 4 min later with a known level of pre-existing locomotor muscle fatigue (DeltaQ(tw,pot) -36%) (PFT(83%)-TT). Second, subjects repeated PFT(67%) and the TT was started 4 min later with a known level of pre-existing locomotor muscle fatigue (DeltaQ(tw,pot) -20%) (PFT(67%)-TT). Finally, a control TT was performed without any pre-existing level of fatigue. Central neural drive during the three TTs was estimated via quadriceps EMG. Increases in pre-existing locomotor muscle fatigue from control TT to PFT(83%)-TT resulted in significant dose-dependent changes in central motor drive (-23%), power output (-14%), and performance time (+6%) during the TTs. However, the magnitude of locomotor muscle fatigue following various TTs was not different (DeltaQ(tw,pot) of -35 to -37%, P = 0.35). We suggest that feedback from fatiguing muscle plays an important role in the determination of central motor drive and force output, so that the development of peripheral muscle fatigue is confined to a certain level.

Indexed as

AdultAlgorithmsElectromyographyExerciseExercise TestHumansLocomotionMaleMotor ActivityMuscle ContractionMuscle FatiguePhysical EnduranceQuadriceps MuscleSomatosensory Cortex

Identifiers

PMID17962334
PMCPMC2375542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.