ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2007
Correlation of immune activation with HIV-1 RNA levels assayed by real-time RT-PCR in HIV-1 subtype C infected patients in Northern India.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Adsorption of Rotavirus, MS2 Bacteriophage and Surface-Modified Silica Nanoparticles to Hydrophobic Matter.Food and environmental virology · 2015Article
- Change-point models to estimate the limit of detection.Statistics in medicine · 2013Article
- Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children.PloS one · 2012Article
- Current practices in laboratory monitoring of HIV infection.The Indian journal of medical research · 2011Review
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Authors and funding
6 authors.
Funding
Abstract
backgroundAssays with specificity and cost effectiveness are needed for the measurement of HIV-1 burden to monitor disease progression or response to anti-retroviral therapy (ART) in HIV-1 subtype C infected patients.
objectivesThe objective of this study was to develop and validate an affordable one step real-time RT-PCR assay with high specificity and sensitivity to measure plasma HIV-1 loads in HIV-1 subtype C infected patients.
resultsWe developed an RT-PCR assay to detect and quantitate plasma HIV-1 levels in HIV-1 subtype C infected patients. An inverse correlation between plasma viral loads (PVL) and CD4+ T-cell numbers was detected at all CDC stages. Significant correlations were found between CD8+ T-cell activation and PVL, as well as with the clinical and immunological status of the patients.
conclusionsThis RT-PCR assay provides a sensitive method to measure PVL in HIV-1 subtype C infected patients. Viral loads correlated with immune activation and can be used to monitor HIV care in India.
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