Evidence map›Paper›PMID 17962065›Full record

ReviewProgress in retinal and eye research2008

Zebrafish: a model system for the study of eye genetics.

James M Fadool, John E Dowling

Abstract readReview
In one paragraph

Review in Progress in retinal and eye research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Animal Models in Eye Research: Focus on Corneal Pathologies.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Crk adaptor proteins are necessary for the development of the zebrafish retina.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Review

49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James M FadoolDepartment of Biological Science, Graduate Program in Neuroscience, Florida State University, Tallahassee, FL 32312, USA. jfadool@bio.fsu.edu
John E Dowling

Funding

ANATOMICAL AND BIOCHEMICAL ORGANIZATION OF THE RETINAR01EY000811 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1985 to 2010
$5.2M
Developing Models of Retinal and Eye DefectsR01EY017753 · NEI · FLORIDA STATE UNIVERSITY · PI FADOOL, JAMES M · 2006 to 2010
$1.6M
TRANSGENIC ANAYLSIS OF RETINAL DEVELOPMENT IN VERTEBRATER01EY013020 · NEI · FLORIDA STATE UNIVERSITY · PI FADOOL, JAMES M · 1999 to 2003
$1.1M
FUNCTIONAL ORGANIZATION OF VISUAL SYSTEMSR01EY000824 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1985 to 2002
$1.0M
ANATOMICAL AND BIOCHEMICAL ORGANIZATION OF THE RETINAR37EY000811 · NEI · HARVARD UNIVERSITY · PI DOWLING, JOHN E · 1987 to 1996
–
NEI NIH HHS EY00811NEI NIH HHS EY00824NEI NIH HHS EY017753NEI NIH HHS R01 EY000811NEI NIH HHS R01 EY000824NEI NIH HHS R01 EY013020NEI NIH HHS R01 EY017753
6 · The paper itself

Abstract

Over the last decade, the use of the zebrafish as a genetic model has moved beyond the proof-of-concept for the analysis of vertebrate embryonic development to demonstrated utility as a mainstream model organism for the understanding of human disease. The initial identification of a variety of zebrafish mutations affecting the eye and retina, and the subsequent cloning of mutated genes have revealed cellular, molecular and physiological processes fundamental to visual system development. With the increasing development of genetic manipulations, sophisticated techniques for phenotypic characterization, behavioral approaches and screening strategies, the identification of novel genes or novel gene functions will have important implications for our understanding of human eye diseases, pathogenesis, and treatment.

Indexed as

AnimalsDisease Models, AnimalEye DiseasesGenetic TechniquesZebrafish

Identifiers

PMID17962065
PMCPMC2271117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.