ArticleBMC health services research2007
Impact of prescription size on statin adherence and cholesterol levels.
Article in BMC health services research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of the predictors of statin adherence for the primary prevention of cardiovascular disease.PloS one · 2019Pooled it
- Impact of issuing longer- versus shorter-duration prescriptions: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018Pooled it
- Prevalence and associated factors of non-adherence to antihyperlipidemic medication: a nationwide cross sectional survey in Pakistan.Scientific reports · 2024Article
- Assessing multilevel barriers to hydroxyurea adherence in youth with sickle cell disease using pharmacy-based refill records.Pediatric blood & cancer · 2024Article
- Impact of prescription length supply policy on patient medication adherence in Thailand.BMC health services research · 2023Article
- Statin treatment effectiveness and the SLCO1B1*5 reduced function genotype: Long-term outcomes in women and men.British journal of clinical pharmacology · 2022Article
- Article
- Association Between Cost-Saving Prescription Policy Changes and Adherence to Chronic Disease Medications: an Observational Study.Journal of general internal medicine · 2022Observational
- Determinants of Non-Adherence to the Medications for Dyslipidemia: A Systematic Review.Patient preference and adherence · 2021Review
- Patients' Experiences with Refilling their HIV Medicines: Facilitators and Barriers to On-Time Refills.The Permanente journal · 2020Article
- Length of Initial Prescription at Hospital Discharge and Long-Term Medication Adherence for Elderly, Post-Myocardial Infarction Patients: Protocol for an Interrupted Time Series Study.JMIR research protocols · 2020Article
- Evaluation of the Effectiveness of a Patient-Centered Educational Mailer Designed to Improve Statin Adherence: A Pragmatic Trial.EGEMS (Washington, DC) · 2016Article
- Improving Medication Routines and Adherence in Hypertensive African Americans: Finding the Needle in the Haystack.Journal of clinical hypertension (Greenwich, Conn.) · 2015Article
- Increasing Prescription Length Could Cut Cardiovascular Disease Burden And Produce Savings In South Africa.Health affairs (Project Hope) · 2015Article
- Health care system-level factors associated with performance on Medicare STAR adherence metrics in a large, integrated delivery system.Medical care · 2015Article
- Influence of refill adherence method when comparing level of adherence for different dosing regimens.European journal of clinical pharmacology · 2014Article
- Association of thiazolidinediones with gastric cancer in type 2 diabetes mellitus: a population-based case-control study.BMC cancer · 2013Article
- Standardizing terminology and definitions of medication adherence and persistence in research employing electronic databases.Medical care · 2013Article
- Adherence to chronic disease medications among New York City Medicaid participants.Journal of urban health : bulletin of the New York Academy of Medicine · 2013Article
- How patient cost-sharing trends affect adherence and outcomes: a literature review.P & T : a peer-reviewed journal for formulary management · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundTherapy with 3-Hydroxy-3-methylglutaryl Co-enzyme A reductase inhibitors (statins) improve outcomes in a broad spectrum of patients with hyperlipidemia. However, effective therapy requires ongoing medication adherence; restrictive pharmacy policies may represent a barrier to successful adherence, particularly among vulnerable patients. In this study we sought to assess the relationship between the quantity of statin dispensed by the pharmacy with patient adherence and total cholesterol.
methodsWe analyzed a cohort of 3,386 patients receiving more than one fill of statin medications through an integrated, inner-city health care system between January 1, 2000 and December 31, 2002. Our measure of adherence was days of drug acquisition divided by days in the study for each patient, with adequate adherence defined as > or = 80%. Log-binomial regression was used to determine the relative risk of various factors, including prescription size, on adherence. We also assessed the relationship between adherence and total cholesterol using multiple linear regression.
resultsAfter controlling for age, gender, race, co-payment, comorbidities, and insurance status, patients who obtained a majority of fills as 60-day supply compared with 30-day supply were more likely to be adherent to their statin medications (RR 1.41, 95% CI 1.28-1.55, P < 0.01). We found that statin non-adherence less than 80% was predictive of higher total serum cholesterol by 17.23 +/- 1.64 mg/dL (0.45 +/- 0.04 mmol/L).
conclusionIn a healthcare system serving predominantly indigent patients, the provision of a greater quantity of statin medication at each prescription fill contributes to improved adherence and greater drug effectiveness.
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Registered trials
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