ArticleBMC microbiology2007
Characterisation of mycobacteria isolated from slaughter cattle in pastoral regions of Uganda.
Article in BMC microbiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Spoligotype analysis ofZoonoses and public health · 2022Article
- A new nomenclature for the livestock-associatedOpen research Europe · 2021Article
- Retrospective Analysis of Archived Pyrazinamide ResistantMicroorganisms · 2019Article
- Systemic mycobacteriosis caused by 'Mycobacterium avium subspecies hominissuis' in a 14-month-old Japanese black beef steer.The Journal of veterinary medical science · 2017Article
- Isolation and Potential for Transmission of Mycobacterium bovis at Human-livestock-wildlife Interface of the Serengeti Ecosystem, Northern Tanzania.Transboundary and emerging diseases · 2017Article
- Prevalence of tuberculous lesion in cattle slaughtered in Mubende district, Uganda.BMC veterinary research · 2017Article
- Direct detection of Mycobacterium tuberculosis complex in bovine and bubaline tissues through nested-PCR.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2014Article
- Prevalence of bovine tuberculosis in slaughter cattle in Kenya: a postmortem, microbiological and DNA molecular study.Tropical animal health and production · 2012Article
- Mycobacterium bovis infections in slaughter pigs in Mubende district, Uganda: a public health concern.BMC veterinary research · 2012Article
- Diversity of Mycobacterium avium subsp. hominissuis mycobacteria causing lymphadenitis, France.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Factors associated with severity of bovine tuberculosis in Ethiopian cattle.Tropical animal health and production · 2012Article
- Non-tuberculous mycobacteria isolated from slaughter pigs in Mubende district, Uganda.BMC veterinary research · 2012Article
- Isolation of non-tuberculous mycobacteria from pastoral ecosystems of Uganda: public health significance.BMC public health · 2011Article
- African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa.Journal of bacteriology · 2011Article
- Pathology of camel tuberculosis and molecular characterization of its causative agents in pastoral regions of Ethiopia.PloS one · 2011Article
- Factors associated with pastoral community knowledge and occurrence of mycobacterial infections in human-animal interface areas of Nakasongola and Mubende districts, Uganda.BMC public health · 2010Article
- Molecular characterization of Mycobacterium bovis isolates from Ethiopian cattle.BMC veterinary research · 2010Article
- Bayesian receiver operating characteristic estimation of multiple tests for diagnosis of bovine tuberculosis in Chadian cattle.PloS one · 2009Article
- Isolation and characterization of Mycobacterium bovis strains from indigenous Zambian cattle using Spacer oligonucleotide typing technique.BMC microbiology · 2009Article
- African 1, an epidemiologically important clonal complex of Mycobacterium bovis dominant in Mali, Nigeria, Cameroon, and Chad.Journal of bacteriology · 2009Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBovine tuberculosis is a zoonotic problem in pastoral cattle and communities in Uganda. Tuberculin tests in pastoral cattle had shown a high herd but low animal prevalence, with a high proportion of avian reactors. No work had been done to identify the mycobacterial species involved. The objective of the study was to isolate and characterise Mycobacterial species causing tuberculous lesions in slaughtered animals. Lesioned organs compatible with bovine tuberculosis in slaughtered cattle from pastoral areas in Uganda were collected and cultured to isolate mycobacteria. AccuProbe culture identification kits for the Mycobacterium tuberculosis complex, M. avium complex and M. avium were used to identify the isolates. Spoligotyping and Insertion Sequence (IS) 1311 and IS1245 Restriction Fragment Length Polymorphism analysis (RFLP) were used to further characterise the isolates.
resultsOf the 61 lesioned organs and tissues cultured, 19 isolates were identified as M. bovis, 3 as M. avium subsp.hominissuis, 1 as M. intracellulare, 1 as a mixed culture of M. bovis and M. avium sp. and 1 as M. avium sp. and unidentified mycobacteria. Eleven other mycobacteria outside the tuberculosis and avium complex groups were also isolated. Ten new spoligopatterns grouped into three clusters were identified from M. bovis isolates. Two of the three M. avium subsp.hominissuis isolates showed similar patterns on the IS1311 RFLP but all were different on the IS1245 RFLP.
conclusionThe isolation of M. bovis confirms the ongoing infection with spoligotypes unique to Uganda. Isolation of environmental mycobacteria could explain the high avian or non specific tuberculin reactor patterns commonly observed in pastoral cattle and suggests their pathogenic or opportunistic role in the infection of cattle with disseminated bovine tuberculous lesions.
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