ArticleBMC bioinformatics2007
Estimating genealogies from linked marker data: a Bayesian approach.
Article in BMC bioinformatics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bayesian inference of local trees along chromosomes by the sequential Markov coalescent.Journal of molecular evolution · 2014Article
- Estimation of genealogical coancestry in plant species using a pedigree reconstruction algorithm and application to an oil palm breeding population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Bayesian quantitative trait locus mapping based on reconstruction of recent genetic histories.Genetics · 2009Article
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4 authors.
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Abstract
backgroundAnswers to several fundamental questions in statistical genetics would ideally require knowledge of the ancestral pedigree and of the gene flow therein. A few examples of such questions are haplotype estimation, relatedness and relationship estimation, gene mapping by combining pedigree and linkage disequilibrium information, and estimation of population structure.
resultsWe present a probabilistic method for genealogy reconstruction. Starting with a group of genotyped individuals from some population isolate, we explore the state space of their possible ancestral histories under our Bayesian model by using Markov chain Monte Carlo (MCMC) sampling techniques. The main contribution of our work is the development of sampling algorithms in the resulting vast state space with highly dependent variables. The main drawback is the computational complexity that limits the time horizon within which explicit reconstructions can be carried out in practice.
conclusionThe estimates for IBD (identity-by-descent) and haplotype distributions are tested in several settings using simulated data. The results appear to be promising for a further development of the method.
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