ArticleLasers in surgery and medicine2007
High-field magnetic resonance imaging of the response of human prostate cancer to Pc 4-based photodynamic therapy in an animal model.
Article in Lasers in surgery and medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- An Analysis of the Effects of In Vitro Photodynamic Therapy on Prostate Cancer Tissue by Histopathological Examination and Magnetic Resonance Imaging.International journal of molecular sciences · 2022Article
- Computer-aided Detection of Prostate Cancer with MRI: Technology and Applications.Academic radiology · 2016Review
- Quantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy.PloS one · 2016Article
- Image-guided Interstitial Photodynamic Therapy for Squamous Cell Carcinomas: Preclinical investigation.Journal of oral and maxillofacial surgery, medicine, and pathology · 2015Article
- Targeted iron-oxide nanoparticle for photodynamic therapy and imaging of head and neck cancer.ACS nano · 2014Article
- Nonrigid point registration for 2D curves and 3D surfaces and its various applications.Physics in medicine and biology · 2013Article
- A cell-targeted photodynamic nanomedicine strategy for head and neck cancers.Molecular pharmaceutics · 2013Article
- Biodistribution Study of Nanoparticle Encapsulated Photodynamic Therapy Drugs Using Multispectral Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- Accuracy Evaluation of a 3D Ultrasound-guided Biopsy System.Proceedings of SPIE--the International Society for Optical Engineering · 2013Article
- Animal models of extracranial pediatric solid tumors.Oncology letters · 2012Article
- Hyperspectral imaging and quantitative analysis for prostate cancer detection.Journal of biomedical optics · 2012Article
- 3D ultrasound image segmentation using wavelet support vector machines.Medical physics · 2012Article
- Like a bolt from the blue: phthalocyanines in biomedical optics.Molecules (Basel, Switzerland) · 2011Review
- Automatic Tissue Classification for High-resolution Breast CT Images Based on Bilateral Filtering.Proceedings of SPIE--the International Society for Optical Engineering · 2011Article
- 3-D photoacoustic and pulse echo imaging of prostate tumor progression in the mouse window chamber.Journal of biomedical optics · 2011Article
- Photo-oxidation of cardiolipin and cytochrome c with bilayer-embedded Pc 4.Free radical biology & medicine · 2010Article
- Diffusion-weighted MRI for monitoring tumor response to photodynamic therapy.Journal of magnetic resonance imaging : JMRI · 2010Article
- Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.Chemical reviews · 2010Review
- Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system.The Laryngoscope · 2010Article
- Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models.International journal of radiation oncology, biology, physics · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionHigh-field magnetic resonance imaging (MRI) is an emerging technique that provides a powerful, non-invasive tool for in vivo studies of cancer therapy in animal models. Photodynamic therapy (PDT) is a relatively new treatment modality for prostate cancer, the second leading cause of cancer mortality in American males. The goal of this study was to evaluate the response of human prostate tumor cells growing as xenografts in athymic nude mice to Pc 4-sensitized PDT. MATERIALS AND
methodsPC-3, a cell line derived from a human prostate malignant tumor, was injected intradermally on the back flanks of athymic nude mice. Two tumors were initiated on each mouse. One was treated and the other served as the control. A second-generation photosensitizing drug Pc 4 (0.6 mg/kg body weight) was delivered to each animal by tail vein injection 48 hours before laser illumination (672 nm, 100 mW/cm(2), 150 J/cm(2)). A dedicated high-field (9.4 T) small-animal MR scanner was used for image acquisitions. A multi-slice multi-echo (MSME) technique, permitting noninvasive in vivo assessment of potential therapeutic effects, was used to measure the T2 values and tumor volumes. Animals were scanned immediately before and after PDT and 24 hours after PDT. T2 values were computed and analyzed for the tumor regions.
resultsFor the treated tumors, the T2 values significantly increased (P<0.002) 24 hours after PDT (68.2+/- 8.5 milliseconds), compared to the pre-PDT values (55.8+/-6.6 milliseconds). For the control tumors, there was no significant difference (P = 0.53) between the pre-PDT (52.5+/-6.1 milliseconds) and 24-hour post-PDT (54.3+/-6.4 milliseconds) values. Histologic analysis showed that PDT-treated tumors demonstrated necrosis and inflammation that was not seen in the control. DISCUSSION: Changes in tumor T2 values measured by multi-slice multi-echo MR imaging provide an assay that could be useful for clinical monitoring of photodynamic therapy of prostate tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.