ReviewNeurochemical research2008
Molecular genetics of monoamine transporters: relevance to brain disorders.
Review in Neurochemical research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers.PloS one · 2013Trial
- Ghrelin in Depression: A Promising Therapeutic Target.Molecular neurobiology · 2025Review
- Article
- The contribution of the 5-hydroxytryptamine receptor 2 A gene polymorphisms rs6311 and rs6313 to Schizophrenia in Iran.Molecular biology reports · 2023Article
- Risk Variants in Three Alzheimer's Disease Genes Show Association with EEG Endophenotypes.Journal of Alzheimer's disease : JAD · 2021Article
- No Influence of Dopamine System Gene Variations on Acute Effects of MDMA.Frontiers in psychiatry · 2019Article
- Genetic Interaction Between Two VNTRs in the SLC6A4 Gene Regulates Nicotine Dependence in Vietnamese Men.Frontiers in pharmacology · 2018Article
- Article
- Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2015Article
- Externalizing Problem Behavior in Adolescence: Dopaminergic Genes in Interaction with Peer Acceptance and Rejection.Journal of youth and adolescence · 2015Article
- Characterization of a REST-Regulated Internal Promoter in the Schizophrenia Genome-Wide Associated Gene MIR137.Schizophrenia bulletin · 2015Article
- Association between amygdala reactivity and a dopamine transporter gene polymorphism.Translational psychiatry · 2014Article
- An evaluation of a SVA retrotransposon in the FUS promoter as a transcriptional regulator and its association to ALS.PloS one · 2014Article
- SVA retrotransposons as modulators of gene expression.Mobile genetic elements · 2014Article
- Mechanisms of dopamine transporter regulation in normal and disease states.Trends in pharmacological sciences · 2013Review
- Characterisation of the potential function of SVA retrotransposons to modulate gene expression patterns.BMC evolutionary biology · 2013Article
- Intronic tandem repeat in the serotonin transporter gene in Old World monkeys: a new transcriptional regulator?Journal of molecular neuroscience : MN · 2012Article
- Association between reward-related activation in the ventral striatum and trait reward sensitivity is moderated by dopamine transporter genotype.Human brain mapping · 2011Article
- Behavioural genetics of Alzheimer's disease: a comprehensive review.Archives of medical science : AMS · 2011Article
- Genomic features of the human dopamine transporter gene and its potential epigenetic States: implications for phenotypic diversity.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We have demonstrated in both the human serotonin transporter gene (5HTT) and the dopamine transporter gene (DAT1) that specific polymorphic variants termed Variable Number Tandem Repeats (VNTRs), which correlate with predisposition to a number of neurological and psychiatric disorders, act as transcriptional regulatory domains. We have demonstrated that these domains can act as both tissue-specific and stimulus-inducible regulators of gene expression. As such they can act to be mechanistically associated with the progression or initiation of a behavioural disorder by altering the level of transporter mRNA, which in turn regulates the concentration of transporter in specific cells or in response to a challenge; chemical, environmental or physiological. The synergistic actions of such transcriptional domains will modulate gene expression. Our hypothesis is that these VNTR variants are one mechanism by which nurture can modify concentrations of neurotransmitters in a differential manner.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.