ArticleMolecular genetics and genomics : MGG2008
Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity.
Article in Molecular genetics and genomics : MGG, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A yeast recombination system recapitulates the length polymorphism of a microsatellite implicated in human social behavior.NAR molecular medicine · 2026Article
- The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions.PLoS biology · 2022Article
- Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex.eLife · 2020Article
- An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function.Molecular and cellular biology · 2020Article
- How Acts of Infidelity Promote DNA Break Repair: Collision and Collusion Between DNA Repair and Transcription.BioEssays : news and reviews in molecular, cellular and developmental biology · 2018Review
- Article
- The Arabidopsis THO/TREX component TEX1 functionally interacts with MOS11 and modulates mRNA export and alternative splicing events.Plant molecular biology · 2017Article
- Limited genetic diversity in the PvK12 Kelch protein in Plasmodium vivax isolates from Southeast Asia.Malaria journal · 2016Article
- Nuclear pore components affect distinct stages of intron-containing gene expression.Nucleic acids research · 2015Article
- Coordinated control of replication and transcription by a SAPK protects genomic integrity.Nature · 2013Article
- Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor.The EMBO journal · 2012Article
- Article
- Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.The EMBO journal · 2011Article
- Identification of mRNAs that are spliced but not exported to the cytoplasm in the absence of THOC5 in mouse embryo fibroblasts.RNA (New York, N.Y.) · 2011Article
- Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers.BMC cancer · 2011Article
- AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants.PLoS genetics · 2011Article
- Alterations in the developing testis transcriptome following embryonic vinclozolin exposure.Reproductive toxicology (Elmsford, N.Y.) · 2010Article
- The nuclear pore complex: bridging nuclear transport and gene regulation.Nature reviews. Molecular cell biology · 2010Review
- Competition between the RNA transcript and the nontemplate DNA strand during R-loop formation in vitro: a nick can serve as a strong R-loop initiation site.Molecular and cellular biology · 2010Article
- Transcription termination by nuclear RNA polymerases.Genes & development · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and plays a role in preventing the transcription-associated genetic instability. THO is composed of Tho2, Hpr1, Mft1 and Thp2 subunits, which associate with the Sub2-Yra1 export factors and Tex1 to form the TREX complex. To compare the functional relevance of the different THO/TREX subunits, we determined the effect of their null mutations on mRNA accumulation and recombination. Unexpectedly, we noticed that a full deletion of HPR1, hpr1DeltaK, conferred stronger hyper-recombination phenotype and gene expression defects than did hpr1DeltaH, the allele encoding a C-terminal truncated protein which was used in most previous studies. We show that tho2Delta and, to a lesser extent, hpr1DeltaK are the THO mutations with the highest impact on all phenotypes, and that sub2Delta shows a similar transcription-dependent hyper-recombination phenotype and in vivo transcription impairment as hpr1DeltaK and tho2Delta. Recombination and transcription analyses indicate that THO/TREX mutants share a moderate but significant effect on gene conversion and ectopic recombination, as well as transcription impairment of even short and low GC-content genes. Our data provide new information on the relevance of these proteins in mRNP biogenesis and in the maintenance of genomic integrity.
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