ArticleGenes and immunity2008
Polymorphisms in the endothelin-1 (EDN1) are associated with asthma in two populations.
Article in Genes and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- TheInternational journal of environmental research and public health · 2022Article
- Article
- Article
- Polymorphisms in nitric oxide synthase and endothelin genes among children with obstructive sleep apnea.BMC medical genomics · 2013Article
- Endothelin-1 single nucleotide polymorphisms and risk of pulmonary metastatic osteosarcoma.PloS one · 2013Article
- Profiling of differentially expressed genes using suppression subtractive hybridization in an equine model of chronic asthma.PloS one · 2012Article
- Recent advances in mechanisms and treatments of airway remodeling in asthma: a message from the bench side to the clinic.The Korean journal of internal medicine · 2011Review
- Expression analysis of asthma candidate genes during human and murine lung development.Respiratory research · 2011Article
- Endothelin-1 gene regulation.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Review
- Unifying candidate gene and GWAS Approaches in Asthma.PloS one · 2010Article
- Blood pressure response to potassium supplementation is associated with genetic variation in endothelin 1 and interactions with E selectin in rural Chinese.Journal of hypertension · 2010Article
- Rhinovirus-induced modulation of gene expression in bronchial epithelial cells from subjects with asthma.Mucosal immunology · 2010Article
- Interferon-lambda1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro.Immunology · 2008Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endothelin-1 (EDN1) has been reported to be implicated in the pathophysiology of asthma. Literature results on the genetic association of EDN1 in asthma are inconsistent. Eleven single nucleotide polymorphisms in EDN1 were genotyped in 342 and 100 families from UK and Norway, respectively. Asthma, bronchial hyperreactivity (BHR) and atopic asthma phenotypes were analyzed for the family-based association. Five single nucleotide polymorphisms (SNPs) were associated with asthma (0.0017<or=P<or=0.0291), five with BHR (0.0026<or=P<or=0.0315) and three with atopic asthma (0.0016<or=P<or=0.041) in the UK population. Three SNPs were associated with asthma (0.0041<or=P<or=0.019), seven with BHR (0.0018<or=P<or=0.041) and two with atopic asthma (0.0123<or=P<or=0.0153) in the Norwegian population. A polymorphism (rs1800541) in the promoter region of EDN1 was replicated in the two populations. A nonsynonymous coding polymorphism (rs5370) resulting in a change of amino acid Asn to Lys at position 198 was also replicated. The results of haplotype-based association analyses strongly supported the ones of single SNP associations. This study demonstrates the significant evidence of association between polymorphisms in EDN1 and asthma.
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