ArticleMolecular biology of the cell2008
LARG and mDia1 link Galpha12/13 to cell polarity and microtubule dynamics.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 50 citations in OpenAlex.
- Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells.Applied biochemistry and biotechnology · 2022Article
- GPCRs thatSmall GTPases · 2022Review
- The GPR17 Receptor-A Promising Goal for Therapy and a Potential Marker of the Neurodegenerative Process in Multiple Sclerosis.International journal of molecular sciences · 2020Review
- DYRK1B regulates Hedgehog-induced microtubule acetylation.Cellular and molecular life sciences : CMLS · 2019Article
- A role for planar cell polarity during early endoderm morphogenesis.Biology open · 2017Article
- mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions.Biochemical and biophysical research communications · 2017Article
- An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.Molecular biology of the cell · 2016Article
- Review
- Inhibition of Diaphanous Formin Signaling In Vivo Impairs Cardiovascular Development and Alters Smooth Muscle Cell Phenotype.Arteriosclerosis, thrombosis, and vascular biology · 2015Article
- Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer.Cancer science · 2015Article
- Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis.The American journal of pathology · 2015Article
- Gα12 structural determinants of Hsp90 interaction are necessary for serum response element-mediated transcriptional activation.Molecular pharmacology · 2014Article
- Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration.Molecular biology of the cell · 2014Article
- Tubulin, actin and heterotrimeric G proteins: coordination of signaling and structure.Biochimica et biophysica acta · 2014Review
- The leukemia-associated Rho guanine nucleotide exchange factor LARG is required for efficient replication stress signaling.Cell cycle (Georgetown, Tex.) · 2014Article
- A LARGe surprise links ATR and Rho.Cell cycle (Georgetown, Tex.) · 2014Article
- PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA.Journal of cell science · 2013Article
- Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.Molecular biology of the cell · 2013Article
- Article
- Formins at a glance.Journal of cell science · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of cell polarity is a process observed in all cells. During directed migration, cells orientate their microtubule cytoskeleton and the microtubule-organizing-center (MTOC), which involves integrins and downstream Cdc42 and glycogen synthase kinase-3beta activity. However, the contribution of G protein-coupled receptor signal transduction for MTOC polarity is less well understood. Here, we report that the heterotrimeric Galpha(12) and Galpha(13) proteins are necessary for MTOC polarity and microtubule dynamics based on studies using Galpha(12/13)-deficient mouse embryonic fibroblasts. Cell polarization involves the Galpha(12/13)-interacting leukemia-associated RhoGEF (LARG) and the actin-nucleating diaphanous formin mDia1. Interestingly, LARG associates with pericentrin and localizes to the MTOC and along microtubule tracks. We propose that Galpha(12/13) proteins exert essential functions linking extracellular signals to microtubule dynamics and cell polarity via RhoGEF and formin activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.