ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Cell-autonomous inhibition of alpha 7-containing nicotinic acetylcholine receptors prevents death of parasympathetic neurons during development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Distribution of α7 Nicotinic Acetylcholine Receptor Subunit mRNA in the Developing Mouse.Frontiers in neuroanatomy · 2019Article
- Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.PloS one · 2018Article
- RARβ regulates neuronal cell death and differentiation in the avian ciliary ganglion.Developmental neurobiology · 2015Article
- Membrane-tethered ligands: tools for cell-autonomous pharmacological manipulation of biological circuits.Physiology (Bethesda, Md.) · 2013Review
- Differential effects of RET and TRKB on axonal branching and survival of parasympathetic neurons.Developmental neurobiology · 2013Article
- Tethering toxins and peptide ligands for modulation of neuronal function.Current opinion in neurobiology · 2012Review
- Cholinergic modulation of cognitive processing: insights drawn from computational models.Frontiers in behavioral neuroscience · 2012Article
- A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The Terebridae and teretoxins: Combining phylogeny and anatomy for concerted discovery of bioactive compounds.BMC chemical biology · 2010Article
- Neonatal intermittent hypoxia impairs neuronal nicotinic receptor expression and function in adrenal chromaffin cells.American journal of physiology. Cell physiology · 2010Article
- The cortistatin gene PSS2 rather than the somatostatin gene PSS1 is strongly expressed in developing avian autonomic neurons.The Journal of comparative neurology · 2010Article
- Prostate stem cell antigen is an endogenous lynx1-like prototoxin that antagonizes alpha7-containing nicotinic receptors and prevents programmed cell death of parasympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators.Frontiers in molecular neuroscience · 2009Article
- Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides.PloS one · 2009Article
- Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.Molecular cancer therapeutics · 2009Article
- EphB receptors co-distribute with a nicotinic receptor subtype and regulate nicotinic downstream signaling in neurons.Molecular and cellular neurosciences · 2008Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neurotrophic molecules are key retrograde influences of cell survival in the developing nervous system, but other influences such as activity are also emerging as important factors. In the avian ciliary ganglion, half the neurons are eliminated between embryonic day 8 (E8) and E14, but it is not known how cell death is initiated. Because systemic application of alpha7-nicotinic acetylcholine receptor (nAChR) antagonists prevents this cell loss, we examined differences in receptor densities and responses of intracellular calcium to nicotine using the calcium-sensitive dye fura-2. In addition, we determined whether cell-autonomous inhibition of alpha7 activation in neurons prevented cell death. E8 neurons are heterogeneous with respect to alpha7-nAChR density, which leads to large increases in [Ca2+]i in some neurons; E8 neurons also exhibit a slower rate of Ca2+ decay after nicotinic stimulation than E13 neurons. Expressing alpha-bungarotoxin that is tethered to the membrane by a glycosylphosphatidylinositol linkage (GPIalpha btx) in ciliary ganglion neurons with the retroviral vector RCASBP(A) blocks increases in intracellular calcium induced by nicotine through alpha7-nAChRs and prevents neurons from dying. Expression of GPIalpha btx in surrounding non-neural tissues, but not in neurons, does not prevent cell loss. Furthermore, the GPIalpha btx is not efficiently expressed in the accessory oculomotor neurons, eliminating preganglionic inputs as another site for action of the antagonist. These results support the hypothesis that cholinergic inputs facilitate cell death in the developing autonomic nervous system by activating alpha7-nAChRs, possibly by leading to increases in intracellular calcium that exceed the threshold for cell survival.
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Registered trials
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