ArticleJournal of neurophysiology2008
Transient activity induces a long-lasting increase in the excitability of olfactory bulb interneurons.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 17 citations in OpenAlex.
- Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model.PLoS computational biology · 2026Article
- Functional Specialization of Interneuron Dendrites: Identification of Action Potential Initiation Zone in Axonless Olfactory Bulb Granule Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Generative Biophysical Modeling of Dynamical Networks in the Olfactory System.Methods in molecular biology (Clifton, N.J.) · 2018Article
- A coupled-oscillator model of olfactory bulb gamma oscillations.PLoS computational biology · 2017Article
- Unified thalamic model generates multiple distinct oscillations with state-dependent entrainment by stimulation.PLoS computational biology · 2017Article
- Granule cell excitability regulates gamma and beta oscillations in a model of the olfactory bulb dendrodendritic microcircuit.Journal of neurophysiology · 2016Article
- Biophysical constraints on lateral inhibition in the olfactory bulb.Journal of neurophysiology · 2016Article
- Comparison of realistic and idealized breathing patterns in computational models of airflow and vapor dosimetry in the rodent upper respiratory tract.Inhalation toxicology · 2016Article
- Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cells.Journal of neurophysiology · 2015Article
- Regulation of persistent activity in hippocampal mossy cells by inhibitory synaptic potentials.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- A two-layer biophysical model of cholinergic neuromodulation in olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Impact of infralimbic inputs on intercalated amygdala neurons: a biophysical modeling study.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Article
- Excitatory actions of noradrenaline and metabotropic glutamate receptor activation in granule cells of the accessory olfactory bulb.Journal of neurophysiology · 2009Article
- Reconstructing the Population Activity of Olfactory Output Neurons that Innervate Identifiable Processing Units.Frontiers in neural circuits · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Little is known about the cellular mechanisms that underlie the processing and storage of sensory in the mammalian olfactory system. Here we show that persistent spiking, an activity pattern associated with working memory in other brain regions, can be evoked in the olfactory bulb by stimuli that mimic physiological patterns of synaptic input. We find that brief discharges trigger persistent activity in individual interneurons that receive slow, subthreshold oscillatory input in acute rat olfactory bulb slices. A 2- to 5-Hz oscillatory input, which resembles the synaptic drive that the olfactory bulb receives during sniffing, is required to maintain persistent firing. Persistent activity depends on muscarinic receptor activation and results from interactions between calcium-dependent afterdepolarizations and low-threshold Ca spikes in granule cells. Computer simulations suggest that intrinsically generated persistent activity in granule cells can evoke correlated spiking in reciprocally connected mitral cells. The interaction between the intrinsic currents present in reciprocally connected olfactory bulb neurons constitutes a novel mechanism for synchronized firing in subpopulations of neurons during olfactory processing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.